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As transcranial direct current stimulation (tDCS) is likely dependent on NMDAR neurotransmission, this preliminary study, conducted in 30 healthy volunteers, assessed the off-line effects of prefrontal anodal tDCS and sham (placebo) treatment on 40-Hz ASSR and aeGBR. Anodal tDCS failed to alter aeGBR but increased both 40-Hz ASSR power, as measured by event-related spectral perturbations (ERSP), and phase locking, as measured by inter-trial phase consistency (ITPC). Inter-individual differences in tDCS-induced increases in ERSP were negatively related to baseline ERSPs. These findings provide tentative support for further study of tDCS as a potential NMDAR neuromodulatory intervention for synchronized auditory gamma response deficits.<\/jats:p>","DOI":"10.1177\/15500594221098285","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T03:10:05Z","timestamp":1651461005000},"page":"472-483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Synchronized Auditory Gamma Response to Frontal Transcranial Direct Current Stimulation (tDCS) and its Inter-Individual Variation in Healthy Humans"],"prefix":"10.1177","volume":"53","author":[{"given":"Sara","family":"de la Salle","sequence":"first","affiliation":[{"name":"The Royal\u2019s Institute of Mental Health Research, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urusa","family":"Shah","sequence":"additional","affiliation":[{"name":"Neuroscience, Carleton 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