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Electrophysiological markers can address this issue. Methods: Pretreatment quantitative electroencephalography (qEEG) records of patients diagnosed with major depressive disorder (MDD) or BD at the first visit were included in the study. Patients with MDD were also grouped with manic switch (MS) or MDD based on the diagnosis of later visits. The qEEG spectral power was analyzed across 3 groups, that is, MS, MDD, and BD. Results: Compared to patients whose diagnosis did not change, patients with MS had accelerated high-frequency activities predominantly in the left hemisphere (central-parietal-occipital regions). In contrast, they showed increased slow wave activity predominantly in the right hemisphere (parietal-occipital regions). Conclusion: It can be concluded that searching for electrophysiological markers, which have distinct advantages of repeatability, noninvasiveness, and cost-effectiveness, can facilitate the prediction of the MS.<\/jats:p>","DOI":"10.1177\/15500594231190278","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T02:27:02Z","timestamp":1690856822000},"page":"192-202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive Value of qEEG in Manic Switch of Depressed Patients"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-6555","authenticated-orcid":false,"given":"Mehmet Kemal","family":"Ar\u0131kan","sequence":"first","affiliation":[{"name":"Kemal Ar\u0131kan Psychiatry Clinic, Istanbul, 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