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However, chronic lithium therapy or acute overdose can lead to toxicity, with symptoms predominantly observed in individuals with a psychiatric history. Clinical manifestations of lithium toxicity are primarily neurologic and gastrointestinal. This article presents the diagnosis and treatment of a case of lithium toxicity, incorporating an analysis of the literature on the characteristics of wakeful EEG before and after treatment in relation to serum lithium levels. It was found that EEG, as an adjunctive examination in lithium-induced encephalopathy, serves as a sensitive tool for assessing lithium-related neurotoxicity, facilitating the safe management of manic disorders and other psychiatric conditions treated with lithium carbonate.<\/jats:p>","DOI":"10.1177\/15500594261455079","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:42:53Z","timestamp":1780393373000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamics of Wakeful EEG Correlated with Serum Lithium Concentration Before and After Treatment of Lithium Carbonate Toxicity: A Case Report and Literature Review"],"prefix":"10.1177","author":[{"given":"Hongmei","family":"Han","sequence":"first","affiliation":[{"name":"The Second Hospital of Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5085-5021","authenticated-orcid":false,"given":"Baohui","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta17540"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14212"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12482"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-246499"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8052471"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43678-024-00796-z"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290048013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03191-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.07.028"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.05.021"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000801"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000769"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00849.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12685"},{"issue":"5","key":"e_1_3_3_16_2","first-page":"169","article-title":"Is the EEG helpful in diagnosing and monitoring lithium intoxication? A case report and review of the literature","volume":"33","author":"Gallinat J","unstructured":"Gallinat J, Boetsch T, Padberg F, Hampel H, Herrmann WM, Hegerl U. Is the EEG helpful in diagnosing and monitoring lithium intoxication? A case report and review of the literature. Pharmacopsychiatry. 2000 Sep;33(5):169\u2013173. 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