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Although this problem is transversal to every digital service, it is especially relevant when critical and personal information is managed, as in eHealth and well-being services. During the last years, many different innovative services in this area have been proposed. However, data management challenges are still in need of a solution. In general, data are directly sent to services but no trustworthy instruments to recover these data or remove them from services are available. In this scheme, services become the users\u2019 data owners although users keep the rights to access, modify, and be forgotten. Nevertheless, the adequate implementation of these rights is not guaranteed, as services use the received data with commercial purposes. In order to address and solve this situation, we propose a new trustworthy personal data protection mechanism for well-being services, based on privacy-by-design technologies. This new mechanism is based on Blockchain networks and indirection functions and tokens. Blockchain networks execute transparent smart contracts, where users\u2019 rights are codified, and store the users\u2019 personal data which are never sent or given to external services. Besides, permissions and privacy restrictions designed by users to be applied to their data and services consuming them are also implemented in these smart contracts. Finally, an experimental validation is also described to evaluate the Quality of Experience (in terms of user satisfaction) and Quality of Service (in terms of processing delay) compared to traditional service provision solutions. <\/jats:p>","DOI":"10.1177\/1550147720912110","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T11:01:15Z","timestamp":1588676475000},"page":"155014772091211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Enabling trustworthy personal data protection in eHealth and well-being services through privacy-by-design"],"prefix":"10.1177","volume":"16","author":[{"given":"Tom\u00e1s","family":"Robles","sequence":"first","affiliation":[{"name":"Universidad Polit\u00e9cnica de Madrid, Madrid, 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