{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:07:17Z","timestamp":1777943237097,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                    Introduction. Peritoneal insufflation with warm-humidified (WH) CO\n                    <jats:sub>2<\/jats:sub>\n                    gas during minimally invasive surgical procedures is purported to prevent hypothermia and peritoneal desiccation and is associated with decreased postoperative IL-6 levels. This randomized study\u2019s purpose was to determine the clinical impact of WH versus cold-dry (CD) CO\n                    <jats:sub>2<\/jats:sub>\n                    in minimally invasive colon resection (MICR), and to assess perioperative plasma levels of IL-6, TIMP-1, sVEGF-R1, and HSP-70 after MICR. Methods. Operative and short-term clinical data plus perioperative blood samples were collected on MICR patients randomized to receive either WH (36.7\u00b0C, 95% humidity) or CD (room temperature, 0% humidity) CO\n                    <jats:sub>2<\/jats:sub>\n                    perioperatively. Peritoneal biopsies were taken at the start and end of surgery. Outcomes tracked included core temperature, postoperative in-hospital pain levels, analgesia requirements, and standard recovery parameters. Preoperative and postoperative days (PODs) 1 and 3 plasma protein levels were determined via ELISA. Results. A total of 101 patients were randomized to WH CO\n                    <jats:sub>2<\/jats:sub>\n                    (50) or CD CO\n                    <jats:sub>2<\/jats:sub>\n                    (51). The WH group contained more diabetics ( P = .03). There were no differences in indication, minimally invasive surgical method used, or core temperature. Pain scores were similar; however, the WH patients required less narcotics on PODs 1 to 3 ( P &lt; .05), and less ketorolac on PODs 1 and 2 ( P &lt; .03). No differences in length of stay, complication rates, or time to flatus\/diet tolerance were noted. Plasma levels of the 4 proteins were similar postoperatively. Though insignificant, the WH group had less marked histologic changes on \u201cend-of-case\u201d peritoneal biopsies. Conclusion. This study found significantly lower pain medication requirements for PODs 1 to 3 for the WH group; however, because there were no differences in the pains scores between the groups, firm conclusions regarding WH CO\n                    <jats:sub>2<\/jats:sub>\n                    cannot be made.\n                  <\/jats:p>","DOI":"10.1177\/1553350617715834","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T05:52:31Z","timestamp":1498542751000},"page":"471-482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Warm and Humidified Versus Cold and Dry CO\n                    <sub>2<\/sub>\n                    Pneumoperitoneum in Minimally Invasive Colon Resection: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"24","author":[{"given":"Elie","family":"Sutton","sequence":"first","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"},{"name":"Maimonides Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Bellini","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Grieco","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M. C. Shantha","family":"Kumara","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Yan","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Cekic","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Njoh","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"bibr1-1553350617715834","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2349-9"},{"key":"bibr2-1553350617715834","doi-asserted-by":"publisher","DOI":"10.1007\/s004640080060"},{"key":"bibr3-1553350617715834","volume-title":"United States Pharmacopoeia and the National Formulary Supplements, 26-NF 21","author":"United States Pharmacopeial Convention","year":"2003","edition":"3"},{"key":"bibr4-1553350617715834","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000001"},{"key":"bibr5-1553350617715834","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-1139-2"},{"key":"bibr6-1553350617715834","first-page":"164","volume":"86","author":"Liu Y","year":"2006","journal-title":"Zhonghua Yi Xue Za 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