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On the 2nd, 14th, and 28th postoperative days adhesions were scored, and tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 (MMP-9), degree of fibrosis, and angiogenesis were measured in abrased cecum and in intact parietal peritoneum. Results. Bevacizumab significantly reduced adhesions up to 15% on the 2nd, 52.5% on the 14th, and 55% on the 28th postoperative day, and significantly increased tPA concentrations in peritoneum. PAI-1 was decreased, and a significantly higher tPA\/PAI-1 ratio along with an increase of MMP-9 was measured at all time points. Fibrosis and angiogenesis were significantly lower on the 14th and 28th postoperative days. Conclusions. Local bevacizumab administration has a strong early and late antiadhesive action on rat peritoneum, mediated by changes in the tPA\/PAI-1 and MMP balance in favor of fibrinolysis up to 28 days after operations.<\/jats:p>","DOI":"10.1177\/1553350617729510","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T06:57:32Z","timestamp":1504767452000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Time Course of Bevacizumab (Anti-VEGF) Effect on Rat Peritoneum: Relations Between Antiadhesive Action and Fibrin Regulation Enzymes"],"prefix":"10.1177","volume":"24","author":[{"given":"Aikaterini-Eftychia","family":"Micha","sequence":"first","affiliation":[{"name":"Aristotle University School of Medicine, Thessaloniki, 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