{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:04:33Z","timestamp":1793642673140,"version":"4.5.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"EndoGastric Solutions, Inc","id":[{"id":"https:\/\/ror.org\/00g35nv72","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    Background. Questions remain about the therapeutic durability of transoral incisionless fundoplication (TIF). In this study, clinical outcomes were evaluated at 5 years post-TIF 2.0. Methods. A total of 63 chronic gastroesophageal reflux disease (GERD) sufferers with troublesome symptoms refractory to proton pump inhibitor (PPI) therapy, absent or \u22642 cm hiatal hernia, and abnormal esophageal acid exposure were randomized to the TIF group or PPI group. Following the 6-month evaluation, all patients in the PPI group elected for crossover to TIF; therefore, all 63 patients underwent TIF 2.0 with EsophyX\n                    <jats:sub>2<\/jats:sub>\n                    device. Primary outcome was elimination of daily troublesome regurgitation and atypical symptoms at the 5-year follow-up. Secondary outcomes were improvement in symptom scores, PPI use, reoperations, and patient health satisfaction. The cost-effectiveness of TIF 2.0 was also estimated. Results. Of 63 patients, 60 were available at 1 year, 52 at 3 years, and 44 at 5 years for evaluation. Troublesome regurgitation was eliminated in 88% of patients at 1 year, 90% at 3 years, and 86% at 5 years. Resolution of troublesome atypical symptoms was achieved in 82% of patients at 1 year, 88% at 3 years, and 80% at 5 years. No serious adverse events occurred. There were 3 reoperations by the end of the 5-year follow-up. At the 5-year follow-up, 34% of patients were on daily PPI therapy as compared with 100% of patients at screening. The total GERD Health-related quality-of-life score improved by decreasing from 22.2 to 6.8 at 5 years ( P &lt; .001). Conclusion. In this patient population, the TIF 2.0 procedure provided safe and sustained long-term elimination of troublesome GERD symptoms.\n                  <\/jats:p>","DOI":"10.1177\/1553350618755214","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T08:33:43Z","timestamp":1517906023000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":127,"title":["The TEMPO Trial at 5 Years: Transoral Fundoplication (TIF 2.0) Is Safe, Durable, and Cost-effective"],"prefix":"10.1177","volume":"25","author":[{"given":"Karim S.","family":"Trad","sequence":"first","affiliation":[{"name":"The George Washington University School of Medicine and Health Science, Washington, DC, USA"},{"name":"The George Washington University Medical Faculty Associates, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Livingston Hospital and Healthcare Services, Inc, CAH, Salem, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Prevou","sequence":"additional","affiliation":[{"name":"The George Washington University Medical Faculty Associates, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Simoni","sequence":"additional","affiliation":[{"name":"Advanced Gastroenterology, Inc, Thousand Oaks, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Steffen","sequence":"additional","affiliation":[{"name":"The George Washington University Medical Faculty Associates, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad B.","family":"Shughoury","sequence":"additional","affiliation":[{"name":"Saint Mary Medical Center, Hobart, IN, USA"},{"name":"Internal Medicine Associates, Merrillville, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoon","family":"Raza","sequence":"additional","affiliation":[{"name":"Indiana Medical Research, Elkhart, IN, USA"},{"name":"Unity Surgical Hospital, Mishawaka, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Heise","sequence":"additional","affiliation":[{"name":"Hancock Regional Hospital, Greenfield, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Fox","sequence":"additional","affiliation":[{"name":"Crossville Medical Group, Crossville, TN, USA"},{"name":"Cumberland Medical Center, Crossville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Mavrelis","sequence":"additional","affiliation":[{"name":"Saint Mary Medical Center, Hobart, IN, USA"},{"name":"Internal Medicine Associates, Merrillville, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"bibr1-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.009"},{"key":"bibr2-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13427"},{"key":"bibr3-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1177\/1553350614526788"},{"key":"bibr4-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-174"},{"key":"bibr5-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5252-8"},{"key":"bibr6-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04042.x"},{"key":"bibr7-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9594-9"},{"key":"bibr8-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"bibr9-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03451.x"},{"key":"bibr10-1553350618755214","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"bibr11-1553350618755214","first-page":"217","volume":"183","author":"Velanovich 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