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Materials and Methods. In 5 Wistar rats, the left RW was punctured. SPIONs suspended in hyaluronic gel (5 mg\/mL) were applied in the RW niche and covered by a muscle graft. The nanoparticles were mobilized using a rare earth magnet (0.54 T) held in 4 consecutive positions around the head. The right ear served as control. Hearing function was monitored by auditory brainstem responses (4-32 kHz tone bursts). Results. The auditory thresholds remained unchanged 1 month after the administration. The histological study of the cochleae showed that SPIONs were driven into the scala tympani in the basal turn, the second turn, and the apex. Conclusion. Superparamagnetic nanoparticles can be driven inside the cochlea toward the apex with a preserved hearing up to 1 month in rats.<\/jats:p>","DOI":"10.1177\/1553350619867217","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T05:46:53Z","timestamp":1567489613000},"page":"646-655","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Superparamagnetic Nanoparticle Delivery to the Cochlea Through Round Window by External Magnetic Field: Feasibility and Toxicity"],"prefix":"10.1177","volume":"26","author":[{"given":"Ga\u00eblle","family":"Leterme","sequence":"first","affiliation":[{"name":"Otolaryngology Department, Dijon University Hospital, Dijon, France"},{"name":"Laboratoire Imvia, Universit\u00e9 Bourgogne-Franche-Comt\u00e9, Dijon, 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