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Therefore, we developed a novel endoscopic surgical approach for these patients. Methods: Four patients were enrolled for endoscopic-assisted oropharyngectomy. The oropharyngeal tumor was resected with an adequate margin via a one-surgeon bimanual approach with the aid of a high-resolution videoendoscopic system, scope holder, and designed surgical instruments. The postoperative surgical margin status, trismus status, perioperative complication, average hospital stay, and follow-up period were recorded. Results: The endoscopic-assisted oropharyngectomy was successfully applied in all 4 patients with en bloc tumor excision and adequate free margin status. The mean hospital stay was 6.5\u00a0days, and all patients could tolerate oral diet within 2\u00a0weeks. There was no perioperative complication noted. No tumor recurrence was identified in patients followed up 2\u00a0years after surgery. Conclusion: Endoscopic-assisted oropharyngectomy for patients with trismus and multiple head and neck cancer history is a safe, minimal invasive, and effective treatment choice other than open surgery or CCRT. It provides a safe option for patients with limited mouth opening.<\/jats:p>","DOI":"10.1177\/15533506211002131","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T12:36:52Z","timestamp":1616243812000},"page":"700-705","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic-Assisted Oropharyngectomy for Early Oropharyngeal Cancer in Trismus Patients"],"prefix":"10.1177","volume":"28","author":[{"given":"Chi-Kuang","family":"Young","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-9938","authenticated-orcid":false,"given":"Shiang-Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery, Department of Otolaryngology\u2013Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan"},{"name":"Graduate Institue of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"bibr1-15533506211002131","unstructured":"Global Cancer Observatory. 2018. 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