{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:26Z","timestamp":1787019266860,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Purposes. This study aimed to evaluate long-term outcomes after the application of a corrosive chemical agent for ablation of epithelial tissue as a non-surgical treatment of anal fistulas. Methods. Adult patients with symptomatic perianal fistula were prospectively included in the study. The fistula tract was irrigated with a 5% silver nitrate solution. The primary outcome measured in this study was the rate of clinical healing after long-term follow-up. Factors that may affect healing were also analysed. Results. A total of 186 patients with anal fistula were analysed. After irrigation with silver nitrate, 82 (44%) patients had complete clinical healing during a median follow-up time of 50 (7\u201364) months. Patients with intermittent discharge had a significantly higher rate of complete clinical healing than those with continuous discharge ( P &lt; .04). Fistulas without abscesses or secondary tracts had a significantly higher rate of complete clinical healing than the other types ( P = .007). Conclusion. Chemical ablation of the epithelium of the anal fistula yields promising long-term outcomes in the management of anal fistulas without surgical intervention.<\/jats:p>","DOI":"10.1177\/15533506211006080","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T02:17:56Z","timestamp":1617329876000},"page":"731-737","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Chemical Ablation for Treating Anal Fistulas without Surgical Intervention: Long-Term Results"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-4144","authenticated-orcid":false,"given":"Wafi","family":"Attaallah","sequence":"first","affiliation":[{"name":"Department of General Surgery, Marmara University School of Medicine, Istanbul, 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