{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:58:41Z","timestamp":1789657121910,"version":"4.0.1"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T00:00:00Z","timestamp":1638576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the impact of laparoscopic sleeve gastrectomy (LSG) and gastric bypass (LGB) on gastroesophageal reflux disease (GERD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>GERD was evaluated by the Modified Italian Gastroesophageal reflux disease\u2014Health-Related Quality of Life (MI-GERD-HRQL) questionnaire, pH-manometry, endoscopy, and Rx-esophagogram, before and 12 months after surgery. Based on these exams, patients without GERD underwent LSG, and patients with GERD underwent LGB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen and six patients underwent LSG and LGB, respectively. After LSG, the only statistically significant difference observed at pH-manometry was the median DeMeester score, from 5.7 to 22.7 (P = .0026). De novo GERD occurred in 6 patients (46.2%), with erosive esophagitis in one. The median MI-GERD-HRQL score improved from 3 to 0. Overall, nine patients underwent LGB, but three were lost to follow-up. Preoperative pH-manometry changed the surgical indication from LSG to LGB in 7 out of 9 patients (77.8%). Six patients who underwent LGB completed the study, and at pH-manometry, statistically significant differences were observed in the percentage of total acid exposure time, with the number of reflux episodes lasting &gt;5\u00a0minutes and DeMeester score (P = .009). The median MI-GERD-HRQL score improved from 6.5 to 0. Statistically significant differences were not observed at endoscopy and Rx-esophagogram findings in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LSG has a negative impact on GERD, even in patients without preoperative GERD. LGB confirmed to be the intervention of choice in patients with GERD. Preoperative pH-manometry may identify patients with silent GERD, to candidate them to LGB rather than LSG. pH-manometry should be used more liberally to establish the correct surgical indication on objective grounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15533506211052745","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T04:07:02Z","timestamp":1638590822000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Does Sleeve Gastrectomy Worsen Gastroesophageal Reflux Disease in Obese Patients? A Prospective Study"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-8761","authenticated-orcid":false,"given":"Andrea","family":"Balla","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u201cParide Stefanini\u201d, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u201cParide Stefanini\u201d, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Corallino","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u201cParide Stefanini\u201d, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Meoli","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u201cParide Stefanini\u201d, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Carlotta Sacchi","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Ribichini","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Pronio","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Department of General Surgery and Surgical Specialties \u201cParide Stefanini\u201d, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Badiali","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro M.","family":"Paganini","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u201cParide Stefanini\u201d, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,4]]},"reference":[{"key":"bibr1-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2013.03.013"},{"key":"bibr2-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9203-4"},{"key":"bibr3-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2019.0540"},{"key":"bibr4-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2015.08.507"},{"key":"bibr5-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6344-4"},{"key":"bibr6-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-017-1613-6"},{"key":"bibr7-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2748-9"},{"key":"bibr8-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-1046-4"},{"key":"bibr9-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.20897"},{"key":"bibr10-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2019.07.027"},{"key":"bibr11-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6565403"},{"key":"bibr12-15533506211052745","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2688-4"},{"key":"bibr13-15533506211052745","volume-title":"Indagine conoscitiva 2018, Societ\u00e0 Italiana di Chirurgia dell\u2019Obesit\u00e0 (S.I.C.Ob.)"},{"key":"bibr14-15533506211052745","unstructured":"Linee guida di chirurgia dell\u2019obesit\u00e0. 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