{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:09:15Z","timestamp":1777943355391,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The aim of this study was confirm the efficacy and feasibility of Onyx injection for pancreatic stump management after pancreaticoduodenectomy (PD) and investigate a new Onyx\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Pancreatic Ducts Obliteration (OPDO) scoring system of pancreatic duct obliteration (PDOb) in patients with high risk of Post-Operative Pancreatic Fistula (POPF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      We enrolled ten patients undergoing PDOb with Onyx\n                      <jats:sup>\u00ae<\/jats:sup>\n                      intraoperative controlled injection after elective PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PDOb with Onyx\n                      <jats:sup>\u00ae<\/jats:sup>\n                      controlled injection was classified according to the OPDO scoring system in three degrees: complete 5\/10 (50%), medium 2\/10 (20%) and bad 3\/10 (30%). Increased amylase in abdominal drainage was identified in two patients (20%) with a degree II and III, and resolved spontaneously within a week. A \u201cclinically relevant\u201d POPF (CR-POPF) was observed in one patient (10%) with a degree III and none in the patients with degree I and II.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      We confirm that intraoperative injection of Onyx\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is a valid solution in high-risk POPF patients and our OPDO scoring system allows obtain an intraoperative classification of the degree of PDO to prevent the CR-POPOF; furthermore, it may be suggested that the viscosity of the injected product (Onyx\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) reduce parenchymal fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15533506221120148","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T02:14:16Z","timestamp":1660184056000},"page":"201-204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic Ducts Obliteration With Controlled Injection of Onyx\n                    <sup>\u00ae<\/sup>\n                    : A Proposal of New Onyx\n                    <sup>\u00ae<\/sup>\n                    Pancreatic Ducts Obliteration Scoring System"],"prefix":"10.1177","volume":"30","author":[{"given":"Francesco","family":"Crafa","sequence":"first","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-8225","authenticated-orcid":false,"given":"Serafino","family":"Vanella","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Noviello","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Radiology, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-2045","authenticated-orcid":false,"given":"Enrico","family":"Coppola Bottazzi","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"bibr1-15533506221120148","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.11.014"},{"key":"bibr2-15533506221120148","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.04.088"},{"key":"bibr3-15533506221120148","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002620"},{"key":"bibr4-15533506221120148","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.2013.811842"},{"key":"bibr5-15533506221120148","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.2018.22.3.248"},{"key":"bibr6-15533506221120148","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2020.04.014"},{"key":"bibr7-15533506221120148","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009621.pub3"}],"container-title":["Surgical 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