{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:09:44Z","timestamp":1777943384846,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011919","name":"Federal University of the State of Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laparoscopy represented one of the most innovative surgical techniques approached in the surgery field. Dexmedetomidine association with general anesthesia promotes the response control to trauma by altering the neuroinflammatory reflex, provides better clinical outcomes in the postoperative period and reduces the excessive use of drugs with risk for addiction. This trial aims to evaluate the potential drug treatment of dexmedetomidine on organic function, with the targets in neuroinflammation, perioperative pain control and blood pressure measurements in a medium-sized surgical model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-two patients were randomized in two groups: Sevoflurane and Dexmedetomidine \u2013 A (dexmedetomidine infusion [1\u00a0\u03bcg\/kg loading, .2-.5\u00a0\u03bcg\/kg\/h thereafter]) vs Sevoflurane and Saline .9% - B. Three blood samples were collected at three times: before surgery, 4 to 6\u00a0hours after surgery and 24\u00a0hours postoperatively. The primary outcome was inflammatory and endocrine mediators dosage analisys. Finally, we evaluated pain and opioid use as secondary outcomes, also the hemodynamic values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Dexmedetomidine group A, a reduction of Interleukin 6 was found during 4-6\u00a0hours after surgery. A reduction of IL-10 was noted in the measurement of its values 24\u00a0hours after the procedure, with statistical significance. Also, systolic and diastolic blood pressure, as well heart rate were attenuated, and there was a lower incidence of pain and opioid consumption in the first postoperative hour ( P &lt; .0001) in the anesthetic recovery room.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dexmedetomidine provided anti-inflammatory activity, sympatholytic effect and analgesia with cardiovascular safety. It reinforces the therapeutic nature of highly selective \u03b12-adrenergic agonists when combined within anesthetic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15533506241234591","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T23:05:56Z","timestamp":1708556756000},"page":"137-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunotherapeutic Properties of Dexmedetomidine on Pain Management and Cardiovascular Function in Videolaparoscopic Cholecystectomies: A Randomized, Two-Arm, Double-Blinded, Placebo-Controlled Trial"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-3120","authenticated-orcid":false,"given":"Gustavo Nascimento","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Gaffr\u00e9e e Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-6459","authenticated-orcid":false,"given":"Virna Guedes","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Gaffr\u00e9e e Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Vaz","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anesthesia, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandoval Lage","family":"Sobrinho","sequence":"additional","affiliation":[{"name":"Department of General and Specialized Surgery, Gaffr\u00e9e e Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Gabriel de Cerqueira Campos","family":"Villardi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Gaffr\u00e9e e Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla Mendon\u00e7a do","family":"Sacramento","sequence":"additional","affiliation":[{"name":"Microbiology and Parasitology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Claudio Pereira","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Gaffr\u00e9e e Guinle University Hospital, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossano Kepler","family":"Alvim Fiorelli","sequence":"additional","affiliation":[{"name":"Department of General and Specialized Surgery, Gaffr\u00e9e e Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"bibr1-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.11.519"},{"key":"bibr2-15533506241234591","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v14.i1.1"},{"key":"bibr3-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697932"},{"key":"bibr4-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-018-0954-3"},{"key":"bibr5-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0770-4"},{"key":"bibr6-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0507-7"},{"key":"bibr7-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001083"},{"key":"bibr8-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9906-1"},{"key":"bibr9-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.04.003"},{"key":"bibr10-15533506241234591","doi-asserted-by":"publisher","DOI":"10.4097\/kja.19259"},{"key":"bibr11-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew113"},{"key":"bibr12-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0625-2"},{"key":"bibr13-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202620"},{"key":"bibr14-15533506241234591","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01641"},{"key":"bibr15-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"bibr16-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2019"},{"key":"bibr17-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2120971"},{"key":"bibr18-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1645-x"},{"key":"bibr19-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001691"},{"key":"bibr20-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2017.06.012"},{"key":"bibr21-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191070"},{"key":"bibr22-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3481"},{"key":"bibr23-15533506241234591","doi-asserted-by":"publisher","DOI":"10.3390\/biom12010004"},{"key":"bibr24-15533506241234591","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1014774"},{"key":"bibr25-15533506241234591","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094972"},{"key":"bibr26-15533506241234591","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.119446"},{"key":"bibr27-15533506241234591","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.112176"},{"issue":"10","key":"bibr28-15533506241234591","first-page":"11824","volume":"13","author":"Yang A","year":"2021","journal-title":"Am J Transl Res"},{"key":"bibr29-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1113\/JP271539"},{"key":"bibr30-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.05.002"},{"key":"bibr31-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.0217"},{"key":"bibr32-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2520-7"},{"key":"bibr33-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000403"},{"key":"bibr34-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000630"},{"key":"bibr35-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1290650"},{"key":"bibr36-15533506241234591","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew411"}],"container-title":["Surgical Innovation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15533506241234591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15533506241234591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15533506241234591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:24:13Z","timestamp":1777706653000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15533506241234591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/15533506241234591"],"URL":"https:\/\/doi.org\/10.1177\/15533506241234591","relation":{},"ISSN":["1553-3506","1553-3514"],"issn-type":[{"value":"1553-3506","type":"print"},{"value":"1553-3514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}