{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:39:35Z","timestamp":1792449575122,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Surg Innov"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laparoscopic sleeve gastrectomy (LSG) is the most widely performed bariatric procedure. While advancements like staple line reinforcement (SLR) have reduced hemorrhagic complications, bleeding risks persist. Tranexamic acid (TXA), an antifibrinolytic agent, has shown promise in mitigating bleeding risks in various surgical disciplines, but its efficacy in LSG with SLR remains unexplored. This study aims to evaluate the effect of intraoperative TXA administration on postoperative bleeding outcomes in patients undergoing LSG with oversewing and omentopexy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational cohort study included 233 patients undergoing LSG with oversewing and omentopexy. Patients were divided into 2 groups: 1 received 1\u00a0g of TXA intraoperatively, while the other did not. Hemoglobin differences at 24 and 48 hours postoperatively were the primary outcomes. Secondary outcomes included blood transfusion necessity, re-intervention rates, and 30-day surgical complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant difference in hemoglobin changes at 24 hours (TXA group: 0.8 \u00b1 0.7\u00a0g\/dL, 95% CI: 0.67-0.93; control group: 0.9 \u00b1 0.9\u00a0g\/dL, 95% CI: 0.74-1.06;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.125) or at 48 hours (TXA group: 1.4 \u00b1 1.5\u00a0g\/dL, 95% CI: 1.12-1.68; control group: 1.5 \u00b1 1.4\u00a0g\/dL, 95% CI: 1.25-1.75;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.167) between the groups. No patients required transfusions or re-interventions. Five patients in the control group exhibited hemorrhagic drainage exceeding 150\u00a0mL, while none in the TXA group experienced similar complications. Length of hospital stay and operative time were similar between the groups (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.124 and 0.746, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tranexamic acid may not significantly impact major bleeding complications following LSG with oversewing and omentopexy but appears to reduce minor hemorrhagic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15533506251344055","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T19:04:26Z","timestamp":1748286266000},"page":"409-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Prophylactic Intraoperative Tranexamic Acid Use on Bleeding After Laparoscopic Sleeve Gastrectomy With Omentopexy: A Prospective Cohort Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-5952","authenticated-orcid":false,"given":"Muhammed Said","family":"Dalk\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Department of General Surgery, School of Medicine, Marmara University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-8651","authenticated-orcid":false,"given":"Abdullah","family":"\u015ei\u015fik","sequence":"additional","affiliation":[{"name":"Dr HE Obesity Clinic, Istanbul, Turkey"},{"name":"Health Sciences Faculty, Gedik University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Gen\u00e7t\u00fcrk","sequence":"additional","affiliation":[{"name":"Dr HE Obesity Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merih","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Dr HE Obesity Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Erdem","sequence":"additional","affiliation":[{"name":"Dr HE Obesity Clinic, Istanbul, Turkey"},{"name":"Health Sciences Faculty, Gedik University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-6524","authenticated-orcid":false,"given":"Chetan","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Whittington Hospital, London, UK"},{"name":"University College London, London, UK"},{"name":"Apollo Hospitals Education and Research Foundation, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-022-06332-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2024.01.012"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-024-07196-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100836"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000506456"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-023-07040-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2417-4"},{"issue":"1","key":"e_1_3_4_9_2","first-page":"5","article-title":"Complications associated with laparoscopic sleeve gastrectomy\u2014a review","volume":"16","author":"Wo\u017aniewska P","year":"2021","unstructured":"Wo\u017aniewska P, Diemieszczyk I, Hady HR. Complications associated with laparoscopic sleeve gastrectomy\u2014a review. Prz Gastroenterol. 2021;16(1):5-9.","journal-title":"Prz Gastroenterol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","unstructured":"Dalkili\u00e7 MS Gen\u00e7t\u00fcrk M Yilmaz M Erdem H \u015ei\u015fik A. Minimizing omental bleeding risk following sleeve gastrectomy: assessing the double-line sealing technique. Surg Laparosc Endosc Percutan Tech. 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Efficacy and safety of tranexamic acid in acute haemorrhage. BMJ. 2024;384:e075720.","journal-title":"BMJ"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60835-5"},{"issue":"2","key":"e_1_3_4_20_2","first-page":"e54269","article-title":"The role of tranexamic acid in sleeve gastrectomy: a systematic review and meta-analysis","volume":"16","author":"Al-Juhani A","year":"2024","unstructured":"Al-Juhani A, Sharaf GF, Aseri S, et al. The role of tranexamic acid in sleeve gastrectomy: a systematic review and meta-analysis. 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