{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:48:29Z","timestamp":1787165309479,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HSS Journal\u00ae: The Musculoskeletal Journal of Hospital for Special Surgery"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Background: Cell therapy has become a hot topic in orthopedics, with significant research dedicated to improving physicians\u2019 understanding of its efficacy. However, little is known about patients\u2019 cell therapy knowledge. Questions\/Purposes: The aims of this study were to (1) evaluate patients\u2019 perceptions of cell therapy in orthopedics, (2) determine whether patients have a preference for autologous or allogeneic cell therapy, and (3) assess patient concerns about cell therapy. Methods: Consecutive outpatients of an orthopedic clinic were surveyed from June 2019 to January 2020. All patients were 18 years old or older and being seen for an orthopedic intervention, including rotator cuff repair, anterior cruciate ligament (ACL) reconstruction, arthroscopic meniscectomy, or a cartilage repair procedure such as an osteochondral allograft transplantation or matrix-associated autologous chondrocyte implantation. Results: A total of 50 patients were surveyed (mean age: 53 years). The patients\u2019 average rating for likelihood to use autologous cells was 8.86 \u00b1 2.2 out of 10 and the average rating for likelihood to use allogeneic cells was 6.24 \u00b1 3.3; 46% of patients had no specific concerns about autologous cell therapy, while 28% expressed concerns about efficacy, and 12% had concerns about donor age. The top 2 \u201cmain concerns\u201d about allogeneic cell therapy were disease transmission (30%) and immune reaction (24%). Conclusions: This survey found that patients asserted a preference for autologous cell therapy in orthopedics. Further research is necessary to further elucidate the factors related to cell therapy that are most important to patients.<\/jats:p>","DOI":"10.1177\/15563316211014885","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T08:59:05Z","timestamp":1621673945000},"page":"240-247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Patient Preference and Perception Regarding the Clinical Use of Autologous Versus Allogeneic Cell Therapy in Orthopedic Surgery"],"prefix":"10.1177","volume":"18","author":[{"given":"Claire D.","family":"Eliasberg","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Nemirov","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J. E.","family":"Green","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Melancon","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Rodeo","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"bibr1-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23055"},{"key":"bibr2-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-019-09578-y"},{"key":"bibr3-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24338"},{"key":"bibr4-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.05.037"},{"key":"bibr5-15563316211014885","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v033a14"},{"key":"bibr6-15563316211014885","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2017-0115"},{"key":"bibr7-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.156"},{"key":"bibr8-15563316211014885","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00915"},{"key":"bibr9-15563316211014885","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00793"},{"key":"bibr10-15563316211014885","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.00189"},{"key":"bibr11-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.101B4.BJJ-2019-0013.R1"},{"key":"bibr12-15563316211014885","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.CC.19.00363"},{"key":"bibr13-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.02.008"},{"key":"bibr14-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.007"},{"key":"bibr15-15563316211014885","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6939-15-75"}],"container-title":["HSS Journal\u00ae: The Musculoskeletal Journal of Hospital for Special Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15563316211014885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15563316211014885","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15563316211014885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:47:29Z","timestamp":1777452449000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15563316211014885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,22]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/15563316211014885"],"URL":"https:\/\/doi.org\/10.1177\/15563316211014885","relation":{},"ISSN":["1556-3316","1556-3324"],"issn-type":[{"value":"1556-3316","type":"print"},{"value":"1556-3324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,22]]}}}