{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:13:37Z","timestamp":1783498417012,"version":"3.55.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HSS Journal\u00ae: The Musculoskeletal Journal of Hospital for Special Surgery"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Primary spine\/pelvic tumors are aggressive, and en bloc resection is often essential. While stereotactic navigation is increasingly used for instrumentation in spine surgery, its specific role in tumor resection remains incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>We sought to describe (1) reported rates of achieving negative margins, (2) local recurrence, (3) complications attributed to navigation, and (4) comparative outcomes from studies involving nonnavigated controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a systematic review according to preferred reporting items for systematic reviews and meta-analysis guidelines. Databases were queried for studies investigating the use of stereotactic navigation in primary spine\/pelvic tumor surgery. Outcomes including surgical margin status, local recurrence, and complications were extracted and qualitatively synthesized using a best-evidence approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-one studies with 240 patients were included. The mean patient age was 46\u2009years with follow-up of 33.4\u2009months. Tumors were most often located in the sacrum\/pelvis (81.3%), followed by the thoracic (8.3%), cervical (5.8%), and lumbar spine (4.6%). Chordoma (31.7%) and chondrosarcoma (27.1%) were the most frequently reported types. Negative surgical margins were achieved in 88.3% of cases. Local recurrence was reported in 16% of patients, with the highest observed in chondrosarcoma (32.4%). Complications occurred in 30.3% of patients; however, only 1% (2 cases) were attributed to navigation use. Two comparative studies examining navigated versus nonnavigated cohorts suggested improved bony margins and lower recurrence risk with navigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early studies suggest that stereotactic navigation may be a feasible and safe adjunct for the resection of primary spine\/pelvic tumors, particularly in achieving adequate bony margins. However, the current evidence is limited to small retrospective studies with heterogeneity in methodology, tumor type, and follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Level IV: Systematic review of level-III and level-IV studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15563316261418705","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:15:58Z","timestamp":1773756958000},"page":"412-425","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Stereotactic Navigation for Primary Spine and Pelvis Tumor Resection and Reconstruction: A Systematic Review"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-6716","authenticated-orcid":false,"given":"Tejas","family":"Subramanian","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Rehabilitation Medicine, University of Chicago, IL, USA"},{"name":"Department of Orthopedic Surgery, Hospital for Special Surgery, New York City, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Oles","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Sports Medicine, Houston Methodist Hospital, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree M.","family":"Vemu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Sports Medicine, Houston Methodist Hospital, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9451-4103","authenticated-orcid":false,"given":"Stephane","family":"Owusu-Sarpong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Hospital for Special Surgery, New York City, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Vaynrub","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hirase","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY USA"},{"name":"Department of Orthopedic Surgery, UC San Diego Health System, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Dea N Gokaslan Z Choi D Fisher C. 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