{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:30:15Z","timestamp":1787052615649,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"The Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["18H00431"],"award-info":[{"award-number":["18H00431"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breastfeeding Medicine"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Brexpiprazole (BPZ), an antipsychotic drug introduced in 2018, is often used to manage psychiatric conditions. However, the effect of its use on infants whose mothers are receiving BPZ during lactation remains uncertain. Given the limited data on its effects on infants, this study evaluated the safety of its use by mothers during lactation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Three mother\u2013infant pairs were assessed between 2018 and 2023 at Tohoku University Hospital. Each mother continued BPZ monotherapy (1\u20132 mg\/day) during pregnancy and lactation within the first month postpartum, and data on maternal and infant health, as well as withdrawal symptoms or adverse events in newborns and infants, were collected from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No withdrawal symptoms or severe adverse events were noted in any of the three newborns or infants. Mild cases of neonatal jaundice and acne were observed in all three newborns and infants; however, they were considered unrelated to BPZ exposure. Nonetheless, it appears that the drug might have decreased milk supply, as supplemental formula feeding was occasionally necessary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study suggests that BPZ monotherapy (1\u20132 mg\/day) during lactation does not lead to withdrawal symptoms or serious adverse events in newborns or infants within the first month postpartum. This initial evidence may help inform breastfeeding decisions among mothers receiving BPZ monotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15568253251408037","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:09:35Z","timestamp":1770379775000},"page":"275-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Safety of Taking Brexpiprazole During the Lactation Period"],"prefix":"10.1177","volume":"21","author":[{"given":"Akari","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Oyanagi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saya","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyu","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riko","family":"Iwabuchi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasumi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takushi","family":"Hanita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariyasu","family":"Mano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Japanese Society of Psychiatry and Neurology\/Japan Society of Obstetrics and Gynecology. Clinical guide for women with mental health problems during the perinatal period 1st edition. 2022. Available from: https:\/\/www.jspn.or.jp\/uploads\/uploads\/files\/activity\/Clinical_guide_for_women_with_mental_health_problems_during_perinatal_period_details_ver1.2.pdf"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60239-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2024.247"},{"key":"e_1_3_3_5_2","unstructured":"The Japanese Society of Perinatal Mental Health. Perinatal Mental Health Consensus Guide 2023. Available from: http:\/\/pmhguideline.com\/consensus_guide2023.html"},{"key":"e_1_3_3_6_2","unstructured":"Package insert. REXULTI\u00ae 1 mg 2 mg tablets. 2023. Available from: https:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/ResultDataSetPDF\/180078_1179058F1020_1_08 [Last accessed: November1 2024]. (In Japanese)."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001197"},{"key":"e_1_3_3_8_2","volume-title":"Drug and Lactation Database (LactMed\u00ae)","author":"U.S. Department of Health and Human Services","year":"2006","unstructured":"U.S. Department of Health and Human Services. Drug and Lactation Database (LactMed\u00ae). National Institute of Child Health and Human Development: Bethesda, MD; 2006. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK501922\/"},{"key":"e_1_3_3_9_2","volume-title":"Drugs in Pregnancy and Lactation","author":"Briggs GG","year":"2021","unstructured":"Briggs GG, , Freeman RK, , Towers CV, et al. Drugs in Pregnancy and Lactation, 12th ed. Wolters Kluwer: Philadelphia; 2021.","edition":"12"},{"key":"e_1_3_3_10_2","volume-title":"Medications and Mothers\u2019 Milk","author":"Hale TW","year":"2023","unstructured":"Hale TW. Medications and Mothers\u2019 Milk, 20th ed. 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(in Japanese).","journal-title":"Symp Jpn Soc Perinat Neonat Med"},{"issue":"1","key":"e_1_3_3_14_2","first-page":"141","article-title":"Neonatal abstinence syndrome: Assessment and management","volume":"2","author":"Finnegan LP","year":"1975","unstructured":"Finnegan LP, , Connaughton JFJr, , Kron RE, et al. Neonatal abstinence syndrome: Assessment and management. 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