{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:10:47Z","timestamp":1780611047448,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breastfeeding Medicine"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Etanercept is a tumor necrosis factor inhibitor frequently used to control ankylosing spondylitis (AS) in women of reproductive age, yet data on its safety during breastfeeding are limited. We report a case of an infant who developed somnolence, hypotonia, feeding difficulties, and a concomitant infection temporally associated with maternal etanercept therapy during lactation and discuss implications for breastfeeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 33-year-old woman with AS delivered a healthy female infant by cesarean section at 36 + 5 weeks\u2019 gestation and began exclusive breastfeeding. At 11 weeks postpartum, she initiated etanercept 25 mg subcutaneously once weekly for her active disease. During treatment, the infant developed prolonged sleep, somnolence, feeding difficulty, and hypotonia, followed within a week by low-grade fever, cough, and nasal congestion. After three doses, etanercept was discontinued, and she was referred to our teratology information service. Approximately 2 weeks after the last dose, the infant\u2019s respiratory symptoms worsened, and diarrhea developed, prompting emergency admission. Laboratory evaluation showed leukocytosis, elevated C-reactive protein, and a nasopharyngeal swab, which was positive for rhinovirus\/enterovirus. Symptoms resolved with supportive care and azithromycin by treatment days 4\u20135. At 9 months of age, the infant has had no other health issues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This case illustrates the difficulty of interpreting adverse events in breastfed infants exposed to maternal biologic medications. Although current evidence suggests no clinically severe adverse effects, minimal infant exposure, and a low risk of clinically relevant immunosuppression with etanercept during breastfeeding, individualized counseling and careful monitoring of exposed infants remain essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15568253261446227","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:17:53Z","timestamp":1778131073000},"page":"336-340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Possible Association Between Etanercept Use During Breastfeeding and Infant Somnolence, Hypotonia, and Feeding Difficulties: A Case Report and Literature Review"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1159-4413","authenticated-orcid":false,"given":"Burak","family":"Eskiyurt","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey."},{"name":"Training and Research Center, Terafar - Izmir Katip Celebi University Teratology Information, Izmir, Turkey."},{"name":"Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1376-9401","authenticated-orcid":false,"given":"Ersan","family":"Horoz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey."},{"name":"Training and Research Center, Terafar - Izmir Katip Celebi University Teratology Information, Izmir, Turkey."},{"name":"Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4819-8255","authenticated-orcid":false,"given":"Deniz Ceyda","family":"Bak\u0131rl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey."},{"name":"Training and Research Center, Terafar - Izmir Katip Celebi University Teratology Information, Izmir, Turkey."},{"name":"Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Gungor","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey."},{"name":"Training and Research Center, Terafar - Izmir Katip Celebi University Teratology Information, Izmir, Turkey."},{"name":"Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Karadas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey."},{"name":"Training and Research Center, Terafar - Izmir Katip Celebi University Teratology Information, Izmir, Turkey."},{"name":"Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Cem","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey."},{"name":"Training and Research Center, Terafar - Izmir Katip Celebi University Teratology Information, Izmir, Turkey."},{"name":"Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2024.1778"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa268"},{"key":"e_1_3_2_4_1","volume-title":"Goodman & Gilman\u2019s: The pharmacological basis of therapeutics","author":"Brunton LL","year":"2023","unstructured":"3.Brunton LL, , Knollmann BC. 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