{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:19:02Z","timestamp":1792606742122,"version":"4.5.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breastfeeding Medicine"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"\n Objective:<\/jats:title>\n This study aimed to be the first to quantify dimethyl sulfoxide (DMSO) concentrations in human milk after the maternal dosing and estimate the relative infant dose (RID) to assess potential safety concerns.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Human milk samples were obtained at different time points after the mother had received one Rimso-50 treatment. The concentrations of DMSO were then quantified at each time interval by a liquid chromatography-mass spectrometry.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The maximum concentration (Cmax) was observed to be 34.5 \u03bcg\/mL at hour 5 post-treatment. The RID was calculated to be 0.45%, while the estimated infant dose was found to be 2 mg\/kg\/day.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The findings of the study demonstrate that DMSO\u2019s transfer into human milk is minimal. Additionally, the study provides the first quantification of DMSO in human milk.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/15568253261454248","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T09:25:01Z","timestamp":1779528301000},"page":"452-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Bladder to Breast Milk\u2014DMSO Treatment of Interstitial Cystitis"],"prefix":"10.1177","volume":"21","author":[{"given":"Emily","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Speck","sequence":"additional","affiliation":[{"name":"School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-1079","authenticated-orcid":false,"given":"Palika","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, InfantRisk Center, School of Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20687"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2001.002001060.x"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15360288.2018.1476433"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4364-2"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002974"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23204"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)27556-5"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16642.1"},{"issue":"1","key":"e_1_3_3_11_1","first-page":"1","article-title":"Medical use of dimethyl sulfoxide (DMSO)","volume":"5","author":"Swanson BN","year":"1985","unstructured":"10.Swanson BN. Medical use of dimethyl sulfoxide (DMSO). Rev Clin Basic Pharm 1985;5(1\u20132):1\u201333.","journal-title":"Rev Clin Basic Pharm"},{"key":"e_1_3_3_12_1","volume-title":"Drugs and human lactation: a comprehensive guide to the content and consequences of drugs, micronutrients, radiopharmaceuticals, and environmental and occupational chemicals in human milk","author":"Bennett PN","year":"1996","unstructured":"11.Bennett PN., ed. Drugs and human lactation: a comprehensive guide to the content and consequences of drugs, micronutrients, radiopharmaceuticals, and environmental and occupational chemicals in human milk. 2nd ed. Amsterdam; New York: Elsevier, 1996, p.ix, 712 p.","edition":"2"}],"container-title":["Breastfeeding Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15568253261454248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15568253261454248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15568253261454248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:18:39Z","timestamp":1783552719000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15568253261454248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,1]]}},"alternative-id":["10.1177\/15568253261454248"],"URL":"https:\/\/doi.org\/10.1177\/15568253261454248","relation":{},"ISSN":["1556-8253","1556-8342"],"issn-type":[{"value":"1556-8253","type":"print"},{"value":"1556-8342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]}}}