{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:56:43Z","timestamp":1777737403941,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Innovations\ufffd(Phila)"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Heparinization is thought to be mandatory to avoid thromboembolic complications during venoarterial extracorporeal membrane oxygenation (VA-ECMO). However, bleeding complications are common. We report our experience of VA-ECMO without systemic anticoagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospectively assembled database describing all ECMO cases from 2000 to 2008 was analyzed. A heparin coated circuit (Medtronic, Inc., Minneapolis, MN USA) and membrane oxygenator (Quadrox D Bioline oxygenator; MAQUET, Rastatt, Germany) were used in all cases. After the initiation of VA-ECMO support, all coagulation parameters were corrected. No further systemic maintenance anticoagulant was given, except at the time of weaning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-two patients received VA-ECMO support; 20 patients (62.5%) were males with a median age of 52.5 years (interquartile range, 40.4\u201361.1 years). Central and peripheral cannulations were 53% and 47%, respectively. Etiologies of cardiogenic shock were postcardiotomy (75%, n = 24) and as a support to cardiopulmonary resuscitation in 25% of cases (n = 8). Thirty-day mortality was 43.8%. Median duration of ECMO support was 46.3 hours (interquartile range, 26.8\u201387.8 hours). The median number of packed red blood cell transfusions was 18 \u00b1 25. Complications include five patients (16%) with limb ischemia requiring intervention, 15 patients (46.9%) had acute renal failure, two patients had deep vein thrombosis, and two patients had intracardiac clots detected on echocardiograms. No patient had a cerebrovascular event. Incidence of membrane oxygenator failure was low, requiring replacement in three patients; no adverse event occurred during replacement. Fourteen patients (43.8%) were re-explored for bleeding. Fourteen patients (44%) were discharged home and were long-term survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VA-ECMO support without systemic anticoagulation may reduce bleeding complications and transfusion requirement, without increasing the risk of thromboembolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/155698451000500608","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T03:42:12Z","timestamp":1546486932000},"page":"424-429","source":"Crossref","is-referenced-by-count":57,"title":["Thromboembolic Events in Patients on Extracorporeal Membrane Oxygenation without Anticoagulation"],"prefix":"10.1177","volume":"5","author":[{"given":"Yoan","family":"Lamarche","sequence":"first","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Chow","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"B\u00e9dard","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navreet","family":"Johal","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie","family":"Kaan","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin H.","family":"Humphries","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anson","family":"Cheung","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"bibr1-155698451000500608","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2008.07.010"},{"key":"bibr2-155698451000500608","first-page":"1879","volume":"372","author":"Chen 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P.S.","year":"2010","journal-title":"Eur J Cardiothorac Surg."},{"key":"bibr16-155698451000500608","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.suppl_2.II-206"},{"key":"bibr17-155698451000500608","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0903700517"}],"container-title":["Innovations: Technology and Techniques in Cardiothoracic and Vascular 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