{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:43Z","timestamp":1787019283030,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations\ufffd(Phila)"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Percutaneous edge-to-edge mitral valve repair is an evolving procedure with increasing indications for use. The MitraClip\u2122 G4 is the newest device with 4 device options, each with distinct characteristics. While the NTR and XTR clips have been in use, the G4 adds 2 new wider clips with additional features, the NTW and XTW.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed 26 cases employing the MitraClip G4 at our institution from November 2019 to March 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The NTR, XTR, NTW, and XTW clips were used in 3 (11.5%), 0 (0.0%), 16 (61.5%), and 11 (42.3%) cases, respectively. Median mitral regurgitation grade was reduced from 4+ to 1+, though 7 (27%) cases had 2+ residual mitral regurgitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The new G4 device includes simplified instructions for use, the option of a wider clip, controlled gripper actuation, and potential left atrial pressure monitoring. The newest MitraClip G4 device allows for potential improved treatment options for patients with mitral regurgitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15569845211030862","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T04:28:57Z","timestamp":1629692937000},"page":"448-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Initial Experiences with the MitraClip G4: Review of the Novel Device Features"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7390-7784","authenticated-orcid":false,"given":"Christopher W.","family":"Ives","sequence":"first","affiliation":[{"name":"Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane P.","family":"Prejean","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos N.","family":"Vardas","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Von Mering","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa I.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"bibr1-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"bibr2-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.536"},{"key":"bibr3-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"bibr4-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"bibr5-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.065"},{"key":"bibr6-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.062"},{"key":"bibr7-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.021"},{"key":"bibr8-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.094"},{"key":"bibr9-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805374"},{"key":"bibr10-15569845211030862","unstructured":"Abbott Vascular. MitraClip\u2122 NTR\/XTR Clip Delivery System [package insert]. Abbott Vascular website, https:\/\/eifu.abbottvascular.com\/content\/dam\/av\/eifu-us\/EL2123342.pdf (2019, accessed 30 April 2020)."},{"key":"bibr11-15569845211030862","unstructured":"Abbott Vascular. MitraClip\u2122 G4 System [package insert]. Abbott Vascular website, https:\/\/eifu.abbottvascular.com\/content\/dam\/av\/eifu-us\/EL2119397.pdf (2019, accessed 30 April 2020)."},{"key":"bibr12-15569845211030862","unstructured":"Evalve, Inc. MitraClip\n                      \u00ae\n                      Clip Delivery System [package insert]. U.S. Food and Drug Administration website, https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf10\/P100009c.pdf (2013, accessed 8 March 2020)."},{"key":"bibr13-15569845211030862","unstructured":"Abbott Vascular. MitraClip\u2122 NT Clip Delivery System [package insert]. U.S. Food and Drug Administration website, https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf10\/P100009S028D.pdf (2019, accessed 8 March 2020)."},{"key":"bibr14-15569845211030862","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00351-1"},{"key":"bibr15-15569845211030862","unstructured":"Lim SD., Rottbauer W., Mahoney P et al. Contemporary outcomes with MitraClip\u2122 (NTR\/XTR) System in primary mitral regurgitation: results from the Global EXPAND Study. Paper presented at: ACC.20, Chicago, IL, USA, 30 March 2020."}],"container-title":["Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15569845211030862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15569845211030862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15569845211030862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:21:33Z","timestamp":1777461693000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15569845211030862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1177\/15569845211030862"],"URL":"https:\/\/doi.org\/10.1177\/15569845211030862","relation":{},"ISSN":["1556-9845","1559-0879"],"issn-type":[{"value":"1556-9845","type":"print"},{"value":"1559-0879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]}}}