{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:50Z","timestamp":1787019290839,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014418","name":"instytut biologii doswiadczalnej im. m. nenckiego pan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014418","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations\ufffd(Phila)"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Transbronchial lung cryobiopsy (TBLC) is a promising technique that can provide a histologic diagnosis in interstitial lung diseases (ILD) and is an alternative to surgical lung biopsy. The main concerns with the procedure are safety and diagnostic accuracy. The technique is applicable in patients unable to undergo surgical biopsy due to severe comorbidities or when patient transport to the operating room is dangerous. This study reports the initial experience with TBLC on a thoracic surgical service as a first attempt at diagnosis in patients with diffuse parenchymal lung diseases (DPLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between May 2018 and July 2020, 32 patients underwent TBLC using bedside flexible bronchoscopy for suspected ILD on a thoracic surgical endoscopy service. Retrospective evaluation of the procedure details, complications, and diagnostic yield were analyzed and reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 89 pathological samples were obtained (mean 2.8 per patient). Pneumothorax and minor bleeding occurred in 25% and 16.7% of patients, respectively. Sixty-seven percent of complications occurred with use of the 2.4 mm cryoprobe ( P = 0.036). Concordance between the histologic diagnosis and final clinical diagnosis was observed in 62.5% of patients and the pathology guided the final treatment in 71% ( P = 0.027) with Kappa-concordance of 0.60 ( P &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cryobiopsy is becoming part of the diagnostic evaluation in patients with indeterminate DPLD or hypoxemic respiratory failure. TBLC is easy to perform and has a favorable safety profile. Thoracic specialists should consider adding TBLC to their procedural armamentarium as a first option for patients with indeterminate PLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15569845211034506","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T02:09:36Z","timestamp":1627870176000},"page":"463-469","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Lung Cryobiopsy Outside of the Operating Room: A Safe Alternative to Surgical Biopsy"],"prefix":"10.1177","volume":"16","author":[{"given":"Vanessa","family":"Menezes","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Molina","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Pollock","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Morisset","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Lafontaine","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Nasir","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Leduc","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moishe","family":"Liberman","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, CHUM Endoscopic Tracheo-bronchial and Oesophageal Centre, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"key":"bibr1-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"bibr2-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"bibr3-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.048"},{"key":"bibr4-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9507-z"},{"key":"bibr5-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12037"},{"key":"bibr6-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2290"},{"key":"bibr7-15569845211034506","doi-asserted-by":"publisher","DOI":"10.21037\/ccts.2019.11.03"},{"key":"bibr8-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1632OC"},{"key":"bibr9-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1159\/000444089"},{"key":"bibr10-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1159\/000203987"},{"key":"bibr11-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"bibr12-15569845211034506","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.06.96"},{"key":"bibr13-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201610-829OC"},{"key":"bibr14-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1159\/000484055"},{"key":"bibr15-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1159\/000439313"},{"key":"bibr16-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"bibr17-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.05.019"},{"key":"bibr18-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0780-3"},{"key":"bibr19-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078674"},{"key":"bibr20-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12261"},{"key":"bibr21-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.12.057"},{"key":"bibr22-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.05.019"},{"key":"bibr23-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000514"},{"key":"bibr24-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000633"},{"key":"bibr25-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2015.02.001"},{"key":"bibr26-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000612"},{"key":"bibr27-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.048"},{"key":"bibr28-15569845211034506","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/qjmed\/hcw105","volume":"110","author":"Sharp C.","year":"2017","journal-title":"QJM"},{"key":"bibr29-15569845211034506","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30342-X"},{"key":"bibr30-15569845211034506","first-page":"e000443.","volume":"6","author":"Troy LK.","year":"2019","journal-title":"BMJ Open Respir Res"}],"container-title":["Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15569845211034506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15569845211034506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15569845211034506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:21:35Z","timestamp":1777461695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15569845211034506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1177\/15569845211034506"],"URL":"https:\/\/doi.org\/10.1177\/15569845211034506","relation":{},"ISSN":["1556-9845","1559-0879"],"issn-type":[{"value":"1556-9845","type":"print"},{"value":"1559-0879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]}}}