{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:20:02Z","timestamp":1784820002093,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL119857-01A1"],"award-info":[{"award-number":["R01HL119857-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005348","name":"American Association for Thoracic Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Merit Award","award":["I01CX002365-01A1"],"award-info":[{"award-number":["I01CX002365-01A1"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations&amp;#65533;(Phila)"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR), previously reserved for patients of intermediate to prohibitive surgical risk, has now been expanded to patients of any surgical risk with severe aortic stenosis. Bioprostheses are prone to structural valve degeneration (SVD), a progressive and multifactorial process that limits valve durability. As the population undergoing TAVR shifts toward a lower-risk and younger profile, long-term durability is a crucial determinant for patient outcomes. Our objective was to determine the incidence and risk factors of SVD at midterm follow-up in a veteran TAVR population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients undergoing TAVR at our federal facility were retrospectively evaluated for SVD and other endpoints with standardized consensus criteria. Multivariable Cox proportional hazards analysis was performed to evaluate risk factors for mortality and SVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>From 2013 to 2020, 344 patients (median age, 78 years) underwent TAVR. Survival from all-cause mortality was 91.3% at 1 year, 75.1% at 3 years, and 61.7% at 5 years. Cumulative freedom from SVD was 98.2% at 1 year, 96.5% at 3 years, and 93.7% at 5 years. All 13 patients with SVD met hemodynamic criteria, and 1 required intervention. Median time to hemodynamic SVD was 1.04 years. Independent risk factors for SVD included age (hazard ratio [HR] = 0.92, 95% confidence interval [CI]: 0.86 to 0.99) and valve size (HR = 0.19, 95% CI: 0.04 to 0.89).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SVD was evident at a low but detectable rate at 5-year follow-up. Further understanding of TAVR biomechanics as well as continued longer-term follow-up will be essential for informing patient-specific risk of SVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15569845221123259","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T03:09:38Z","timestamp":1665457778000},"page":"382-391","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Midterm Durability and Structural Valve Degeneration of Transcatheter Aortic Valve Replacement in a Federal Facility"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-2565","authenticated-orcid":false,"given":"Rachel","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-3353","authenticated-orcid":false,"given":"Aaron F.","family":"Grober","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-6243","authenticated-orcid":false,"given":"Ramon","family":"Riojas","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimala","family":"Ponna","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendrick A.","family":"Shunk","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Zimmet","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California San Francisco and San Francisco VA Medical Center, CA, USA"},{"name":"Uniformed Services University of the Health Sciences, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ge","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-6747","authenticated-orcid":false,"given":"Elaine E.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California San Francisco and San Francisco VA Medical Center, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.4383"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1033"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.06.028"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.07.38"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.04.115"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.04.091"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.083"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311329"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2019.4.2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx303"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.1404"},{"key":"e_1_3_2_15_2","first-page":"24","article-title":"Evolution of Veterans Affairs transcatheter aortic valve replacement program: the first 100 patients","volume":"27","author":"Yang J","year":"2018","unstructured":"Yang J, Zimmet JM, Ponna VM, et al. 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