{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:35:46Z","timestamp":1778308546313,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010261","name":"Thoracic Surgery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations\ufffd(Phila)"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We tested the feasibility and effectiveness of a percutaneous atrial transseptal extracorporeal membrane oxygenation (ECMO) cannulation strategy in a right ventricular failure (RVF) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed 4 nonsurvival porcine experiments. Percutaneous transseptal access was achieved using a steerable introducer. For guidance, we used fluoroscopy, transesophageal echocardiogram (TEE), and intracardiac echocardiography (ICE). A ProtekDuo rapid deployment cannula (LivaNova, London, UK) was advanced across the septum into the left atrium by 2 to 3 cm. Pulmonary hypertension (PH) was induced by partially clamping the pulmonary artery. ECMO flow was cycled from high (2 to 3 L\/min) to low (0.2 to 0.3 L\/min) over 2 to 3 hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Transseptal access using TEE and fluoroscopy was successful in 1 animal and unsuccessful in 1 animal. ICE provided optimal visualization for the remaining 2 animals. Mean arterial pressure (MAP) was associated immediately and consistently with high versus low ECMO flow rate (mean difference: 29 \u00b1 3.1 mm Hg, P = 0.004) but was not restored to baseline values. RV pressure values were dynamic. Given time to equilibrate, mean RV pressure was restored to a baseline level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Percutaneous right atrium to left atrium transseptal cannulation relieved PH-RVF. MAP was restored to a viable level, and mean RV pressure was restored to a baseline level. Transseptal ECMO shows promise as a cannulation strategy to bridge patients with PH-RVF to lung transplant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15569845231208187","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:57:30Z","timestamp":1700096250000},"page":"583-588","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Percutaneous Transseptal Extracorporeal Membrane Oxygenation to Rescue a Failing Right Ventricle in an Animal Model"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-9343","authenticated-orcid":false,"given":"Rocio","family":"Castillo-Larios","sequence":"first","affiliation":[{"name":"Department of General Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Pollak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-5572","authenticated-orcid":false,"given":"Sanjay","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Brad","family":"Case","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod K.","family":"Guru","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-7239","authenticated-orcid":false,"given":"Mohammad","family":"Alomari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZuoRui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"James L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tathagat","family":"Narula","sequence":"additional","affiliation":[{"name":"Department of Transplant, Division of Pulmonary Transplant, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si M.","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-0331","authenticated-orcid":false,"given":"Ian A.","family":"Makey","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"bibr1-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.576"},{"key":"bibr2-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.07.040"},{"key":"bibr3-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14129"},{"key":"bibr4-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182a91ddb"},{"key":"bibr5-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.12.009"},{"key":"bibr6-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.001"},{"key":"bibr7-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27650"},{"key":"bibr8-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivt074"},{"key":"bibr9-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.07.036"},{"key":"bibr10-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.03.127"},{"key":"bibr11-15569845231208187","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028889"},{"key":"bibr12-15569845231208187","doi-asserted-by":"crossref","DOI":"10.25270\/jic\/22.00005","volume":"34","author":"Bernstein 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