{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:02:22Z","timestamp":1793664142247,"version":"4.5.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations&amp;#65533;(Phila)"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Impella 5.5 (Abiomed, Danvers, MA, USA) is approved by the US Food and Drug Administration (FDA) for mechanical circulatory support for \u226414 days. It is unknown whether prolonged support is associated with worse outcomes. We sought to review our single-center experience with Impella 5.5 and compare outcomes based on support duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed adult patients (\u226518 years old) supported with Impella 5.5 at our institution (May 2020 to April 2023). Patients on prolonged support (&gt;14 days) were compared with those supported for \u226414 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 31 patients supported with Impella 5.5 including 14 (45.2%) supported &gt;14 days. Median support duration for those on prolonged support was 43.5 (interquartile range [IQR] 25 to 63.5) days versus 8 (IQR 6, 13) days for those who were not (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Overall, the device-related complication rate was 9.7% and did not differ between groups (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.08). Overall, 30-day postimplant survival was 71% and did not differ by support duration (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.2). In-hospital mortality was 32% and did not differ between cohorts (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.99). Among those surviving to explant (\n                      <jats:italic>n<\/jats:italic>\n                      = 22), long-term strategy included bridge to durable ventricular assist device (18%,\n                      <jats:italic>n<\/jats:italic>\n                      = 4), cardiac transplant (55%,\n                      <jats:italic>n<\/jats:italic>\n                      = 12), and cardiac recovery (27%,\n                      <jats:italic>n<\/jats:italic>\n                      = 6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>High-risk patients with cardiogenic shock may be supported with Impella 5.5 beyond the FDA-approved duration without increased risk of complications or mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15569845231212157","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:53:53Z","timestamp":1701132833000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Reconsidering FDA Guidelines: A Single-Center Experience of Prolonged Impella 5.5 Support"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6156-1165","authenticated-orcid":false,"given":"Carlos Alberto","family":"Valdes","sequence":"first","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-1022","authenticated-orcid":false,"given":"Griffin","family":"Stinson","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Sharaf","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Jimenez Contreras","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5449-2114","authenticated-orcid":false,"given":"Ahmet","family":"Bilgili","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Vilaro","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Parker","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A. Z.","family":"Al-Ani","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Demos","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Aranda","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bleiweis","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Beaver","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric I.","family":"Jeng","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.10.005"},{"key":"e_1_3_2_3_2","first-page":"75","article-title":"Temporary mechanical circulatory support: a review of the options, indications, and outcomes","volume":"8","author":"Gilotra NA","year":"2014","unstructured":"Gilotra NA, Stevens GR, and . 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Clin Med Insights Cardiol 2014; 8(Suppl 1): 75\u201385.","journal-title":"Clin Med Insights Cardiol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2022.2015323"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.08.041"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.01.067"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1627455"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001796"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/imi.0000000000000009"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.01.1603"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-022-01871-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.04.001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/15569845211013329"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs043"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007155"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(22)01478-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001194"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2022.100072"}],"container-title":["Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15569845231212157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15569845231212157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15569845231212157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:18:59Z","timestamp":1777461539000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15569845231212157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/15569845231212157"],"URL":"https:\/\/doi.org\/10.1177\/15569845231212157","relation":{},"ISSN":["1556-9845","1559-0879"],"issn-type":[{"value":"1556-9845","type":"print"},{"value":"1559-0879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]}}}