{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:51:33Z","timestamp":1777737093039,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"This work was supported by CORCYM S.r.l., that funded all trial-related activities and participated in site selection, data monitoring, trial management and statistical analysis."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innovations\ufffd(Phila)"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report the short-term real-word clinical and hemodynamic performance from the MANTRA study in patients undergoing minimally invasive mitral valve repair (MI-MVr) with the MEMO 4D ring (Corcym S.r.l., Saluggia, Italy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>MANTRA is an ongoing prospective study, evaluating the real-life safety and performance data on Corcym devices. Clinical and echocardiographic core lab\u2013assessed outcomes were collected preoperatively, at discharge, and at follow-up, and Kansas City Cardiomyopathy Questionnaire 12 (KCCQ-12) questionnaires were administrated preoperatively and at 30 days. This analysis focused on patients who underwent MI-MVr with the MEMO 4D semirigid annuloplasty ring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Between July 2021 and October 2023, 97 patients were enrolled in 12 institutions. The mean age at surgery was 59.1 \u00b1 11.9 years with a mean EuroSCORE II of 1.3 \u00b1 1.3. Primary mitral regurgitation (MR) was the most common etiology. The 30-day mortality was 0%, and only 2 reoperations were reported within 30 days (2.1%). Surgery resulted in a marked improvement in patient New York Heart Association class, associated with a clinically significant increase in KCCQ-12 summary score. End-diastolic left ventricular diameter decreased from 55.06 \u00b1 6.86 preoperatively to 50.13 \u00b1 6.57 mm at 30-day follow-up, and left atrial volume decreased from 130.96 \u00b1 50.04 preoperatively to 89.32 \u00b1 39.65 mL at 30 days. Mean mitral pressure gradient was 3.156 \u00b1 1.415 mm Hg. MR decreased significantly, with 44.6% of patients showing less than moderate MR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, MI-MVr with MEMO 4D ring was confirmed to be safe and effective, providing good clinical short-term outcomes, improvement of patient quality of life, and good early hemodynamic performance with optimal reduction of MR severity and preservation of left ventricular function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15569845251338807","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:36:08Z","timestamp":1747884968000},"page":"283-289","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Minimally Invasive Mitral Valve Repair With New-Generation Annuloplasty Ring: Results From the International Prospective MANTRA Study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-7452","authenticated-orcid":false,"given":"Ilir","family":"Hysi","sequence":"first","affiliation":[{"name":"Lens Hospital and Bois Bernard Private Hospital, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-2670","authenticated-orcid":false,"given":"Marco","family":"Di Eusanio","sequence":"additional","affiliation":[{"name":"Ospedali Riuniti Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Kerckhoff Klinik, Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-5812","authenticated-orcid":false,"given":"Nikolaos","family":"Bonaros","sequence":"additional","affiliation":[{"name":"Innsbruck Medical University, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz-, Thorax- und Gef\u00e4\u00dfchirurgie Deutsches Herzzentrum der Charit\u00e9, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Baeza","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Troise","sequence":"additional","affiliation":[{"name":"Poliambulanza Foundation Hospital, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Pacini","sequence":"additional","affiliation":[{"name":"Policlinico S.Orsola-Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pollari","sequence":"additional","affiliation":[{"name":"Klinikum N\u00fcrnberg-Paracelsus Medical University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Santarpino","sequence":"additional","affiliation":[{"name":"Citt\u00e0 di Lecce Hospital, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Argano","sequence":"additional","affiliation":[{"name":"Policlinico Paolo Giaccone, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Badano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istituto Auxologico Italiano, IRCCS, Milano, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Dzemali","sequence":"additional","affiliation":[{"name":"University Hospital of Zurich, Clinic for Cardiac Surgery, Switzerland"},{"name":"City Hospital of Zurich\u2014Triemli, Clinic for Cardiac 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2021.1895457"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.13120"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjtc.2021.10.036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.07.017"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-018-0886-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000357263"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2016.04.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-017-0805-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-023-02270-w"},{"key":"e_1_3_3_13_2","article-title":"Mitral 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Mitral valve repair with the semi-rigid Memo 4D annuloplasty ring: early clinical and echocardiographic outcomes from the MANTRA study. Interdiscip Cardiovasc Thorac Surg 2024; 40: ivae208.","journal-title":"Interdiscip Cardiovasc Thorac Surg"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa799"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv333"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew025"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.001958"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722651"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.10.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.11.030"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.070"},{"key":"e_1_3_3_22_2","first-page":"101032","article-title":"Mitral regurgitation in female patients: sex differences and disparities","volume":"2","author":"Ocher R","year":"2023","unstructured":"Ocher R, May M, Labin J, et al. 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