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However, recent surgical innovations offer potential solutions. These include partial heart transplantation and xenotransplantation. Partial heart transplantation is a new procedure with the potential to address several clinical challenges in treating congenital heart defects. Cardiac xenotransplantation involves the transplantation of genetically modified porcine hearts into humans, offering a potential solution to the shortage of donor organs. Although immunologic barriers and ethical concerns remain, ongoing research aims to mitigate the risks and optimize outcomes, providing hope for patients in need. These innovative surgical approaches offer promising avenues for addressing the critical shortage of donor hearts and with ongoing research, may hold the potential to revolutionize heart transplantation, and improve outcomes for patients facing terminal heart failure.<\/jats:p>","DOI":"10.1177\/15569845251375442","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:09:05Z","timestamp":1759903745000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovations in Heart Transplantation: Partial Heart Transplantation and Xenotransplantation"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9655-611X","authenticated-orcid":false,"given":"Zachary T.","family":"Silvano","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA"},{"name":"Department of Internal Medicine, Florida State University College of Medicine, Tallahassee, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0048-0126","authenticated-orcid":false,"given":"Vincent S.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreeja","family":"Choppara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA"},{"name":"Department of Internal Medicine, Florida State University College of Medicine, Tallahassee, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA"},{"name":"Division of Cardiothoracic Surgery, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herra","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"Division of Research, Alabama College of Osteopathic Medicine, Dothan, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Treffalls","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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