{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:50:18Z","timestamp":1782391818996,"version":"3.54.5"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    Lung cancer (LC), particularly lung adenocarcinoma, is a leading cause of cancer-related mortality, while systemic sclerosis\u2013associated interstitial lung disease (SSc-ILD) is a chronic fibrotic autoimmune disorder. Growing evidence suggests shared molecular mechanisms between these conditions, although their genetic overlap remains insufficiently characterized. In this study, integrative bioinformatics approaches were applied to identify common differentially expressed genes (DEGs) and regulatory networks linking LC and SSc-ILD. Comparative transcriptomic analysis revealed 72 shared DEGs, including 10 hub genes:\n                    <jats:italic toggle=\"yes\">MMP7<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CXCL14<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">CD79A<\/jats:italic>\n                    (upregulated), and\n                    <jats:italic toggle=\"yes\">CXCR2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">IL1A<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">FCAR<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">GRIA1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">IL1R2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CSF3<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">FFAR2<\/jats:italic>\n                    (downregulated). Regulatory network analysis identified key miRNAs (hsa-miR-34a-5p, hsa-miR-126-3p, hsa-miR-335-5p) and central transcription factors (FOS, JUN, NFKB1). Pathway enrichment highlighted interleukin-10 signaling as a critical shared pathway, implicating immune regulation and extracellular matrix remodeling. Molecular docking suggested a potential interaction between doxycycline and MMP7 (binding affinity \u22126.4 kcal\/mol), while X-ray diffraction and Rietveld refinement confirmed its crystalline purity. Additionally, doxycycline demonstrated antibacterial activity against\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    via minimum inhibitory concentration assays. Overall, these findings provide preliminary insights into shared molecular features between LC and SSc-ILD and suggest doxycycline as a potential repurposed candidate warranting further experimental and clinical validation.\n                  <\/jats:p>","DOI":"10.1177\/15578100261454404","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:22:37Z","timestamp":1779895357000},"page":"334-343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Bioinformatics and Structural Assessment Suggest Doxycycline as a Potential Candidate Targeting MMP7 in Lung Cancer and SSc-Associated ILD"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9085-2658","authenticated-orcid":false,"given":"Sanjukta","family":"Dasgupta","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Center for Multidisciplinary Research and Innovations, Brainware University, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moupiya","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Basic Science and Humanities, Office of the Sustainability, Institute of Engineering and Management (IEM), Kolkata, University of Engineering and Management, Kolkata, West Bengal, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhendu","family":"Sadhukhan","sequence":"additional","affiliation":[{"name":"Department of Physics, Basic Science and Humanities, Dr. Sudhir Chandra Sur Institute of Technology and Sports Complex, Kolkata, West Bengal, India."},{"name":"SATIE, ENS Paris-Saclay, CNRS, Paris-Saclay University, Gif-sur-Yvette, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijit","family":"Set","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2024.101955"},{"issue":"8","key":"e_1_3_5_3_1","first-page":"1","article-title":"Methicillin-resistant staphylococcus aureus infection exacerbates NSCLC cell metastasis by up-regulating TLR4\/MyD88 pathway","volume":"62","author":"An J","year":"2016","unstructured":"An J, , Li Z, , Dong Y, et al. Methicillin-resistant staphylococcus aureus infection exacerbates NSCLC cell metastasis by up-regulating TLR4\/MyD88 pathway. 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