{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:43:19Z","timestamp":1789774999295,"version":"4.0.1"},"reference-count":54,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Yanzhao Gold Talent Project of Hebei Province","award":["HJZD202506"],"award-info":[{"award-number":["HJZD202506"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    Chronic low-grade inflammation has been identified as the etiology of disease across the life span; however, the underlying genetic mechanism are poorly understood, and no genetic association study is performed. Here, we quantified chronic low-grade inflammation using the low-grade inflammation score (INFLA-score) and performed a genome-wide association study in a large European cohort of 217,984 individuals, involving 6,134,151 single nucleotide polymorphisms (SNPs). We identified 20,182 SNPs at 194 loci reaching genome-wide significance (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 5 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ), with the lead SNP rs429358 in apolipoprotein E (APOE) showing an extremely low\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value of 8.69 \u00d7 10\n                    <jats:sup>\u2212166<\/jats:sup>\n                    . Gene analysis found 470 genes with\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 2.70 \u00d7 10\n                    <jats:sup>\u22126<\/jats:sup>\n                    (0.05\/18,519), among which phosphodiesterase 4B was most significant (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 1.67 \u00d7 10\n                    <jats:sup>\u221222<\/jats:sup>\n                    ). Among those, 15 SNPs were first reported, including GS1-259H13.10, AC068533.7, AL355490.1, and so on. Tissue expression analysis revealed significant links between genetic variants and chronic low-grade inflammation in spleen and whole blood. Our findings identify variants linked to chronic low-grade inflammation and related inflammatory and cellular regulation traits, and suggest a close association between chronic low-grade inflammation and the spleen.\n                  <\/jats:p>","DOI":"10.1177\/15578100261458847","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:14:38Z","timestamp":1781190878000},"page":"449-458","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-Wide Association Study Identifies Human Genetic Variants Associated with Systemic Chronic Inflammation"],"prefix":"10.1177","volume":"30","author":[{"given":"Jiayi","family":"Xue","sequence":"first","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan, China."},{"name":"Hebei Key Laboratory of Organ Fibrosis, Tangshan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan, China."},{"name":"Tangshan Key Laboratory of Clinical Epidemiology, Tangshan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-6706","authenticated-orcid":false,"given":"Youxin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan, China."},{"name":"School of Public Health, Centre for Precision Medicine, Edith Cowan University, Perth, 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