{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:15:18Z","timestamp":1783210518451,"version":"3.54.6"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    Breast and cervical cancers remain significant causes of cancer-related deaths in women, necessitating the development of effective treatments. This study investigated the repositioning potential of procaterol as a chemosensitizer to increase the efficacy of cisplatin in HeLa and MCF-7 cells. On its own, procaterol showed limited cytotoxicity; however, it significantly inhibited cell viability when combined with low doses of cisplatin. Both colony formation and cell proliferation studies showed a strong inhibition of cell growth, especially in HeLa cells. Similarly, wound-healing studies showed greater inhibition of cell migration in the presence of both drugs than with either drug alone. Live\/dead assays and elevated TNF-\u03b1 (tumour necrosis factor-alpha) expression confirmed apoptosis. The increased generation of reactive oxygen species suggested that HeLa cells are under oxidative stress. Flow cytometric analyses showed that procaterol induced G0\/G1 arrest, cisplatin induced G2\/M arrest, and the combination induced both arrests while significantly decreasing S-phase populations. Procaterol sensitized cisplatin by increasing apoptosis and oxidative stress and inducing cell cycle arrest. As an FDA-approved compound, it can be used as a cost-effective adjuvant for treating breast and cervical cancer. Additional\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    verification and clinical trials are required to establish the translational value of this new combination for the treatment of cervical and breast cancer.\n                  <\/jats:p>","DOI":"10.1177\/15578100261459475","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:26:28Z","timestamp":1781879188000},"page":"409-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Procaterol Enhances Cisplatin-Induced Cytotoxicity via Apoptosis, Oxidative Stress, and Cell Cycle Arrest in Breast and Cervical Cancer Cells"],"prefix":"10.1177","volume":"30","author":[{"given":"Neha","family":"Sajwani","sequence":"first","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giridhara Prema","family":"Suchitha","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S. Keshava","family":"Prasad","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-2839","authenticated-orcid":false,"given":"Shobha","family":"Dagamajalu","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.7.1.49"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.06.005"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3978"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018966506819"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4mo00156g"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2023.0163"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.9985"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0111-2"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15112972"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2022.33.e65"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.5414\/cpp48744"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1935"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20191055"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.46137"},{"issue":"4","key":"e_1_3_3_18_1","first-page":"315","article-title":"A m\u00e9hnyakr\u00e1k gy\u00f3gyszeres kezel\u00e9se [Medical therapy of cervical cancer]","volume":"66","author":"M\u00e1t\u00e9 S","year":"2022","unstructured":"M\u00e1t\u00e9 S. 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