{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:36:27Z","timestamp":1792870587263,"version":"4.5.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    The 5\u2032 mRNA leader regulates translation through its length and upstream open reading frames (uORFs), but its systematic remodeling in cancer remains unclear. We analyzed isoform-weighted 5\u2032 leader features across The Cancer Genome Atlas, the Genotype-Tissue Expression transcriptomes and the Clinical Proteomic Tumor Analysis Consortium proteogenomic cohorts. Tumor-associated shifts frequently opposed normal tissue aging trajectories, with the clearest signals in lung adenocarcinoma and lung squamous cell carcinoma. Raw closed-uORF burden defined the sharpest paired-supported lung cores, whereas residualized closed-uORF burden provided the most stable length-independent signal. Colon adenocarcinoma reproduced the transcriptomic pattern but showed a prominent adjacent-normal field effect, with nontumor colon already shifted toward the tumor pattern relative to healthy colon. Upstream\u2013initiation features did not improve proteome-wide prediction beyond mRNA abundance but showed modest, gene-selective associations within independently prioritized age-opposed lung gene sets. Recurrent proteogenomic anchors included\n                    <jats:italic toggle=\"yes\">SEMA4A, TXNL1, PCDH7, ATP2A2, FOXJ3,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">PLK1<\/jats:italic>\n                    . These findings define an age-opposed, tissue-dependent pattern of 5\u2032 leader remodeling and prioritize specific genes and isoforms for functional investigation.\n                  <\/jats:p>","DOI":"10.1177\/15578100261479259","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:17:09Z","timestamp":1787055429000},"page":"729-744","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-0295","authenticated-orcid":false,"given":"Ayon","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Botany, Microbiology and Computational Biology Laboratory, Raiganj University, Raiganj, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranav","family":"Pal","sequence":"additional","affiliation":[{"name":"Sarat Chandra Chattopadhyay Government Medical College and Hospital, Howrah, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Zoology, Raiganj University, Raiganj, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita G.","family":"Chaki","sequence":"additional","affiliation":[{"name":"Department of Botany, Microbiology and Computational Biology Laboratory, Raiganj University, Raiganj, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Botany, Microbiology and Computational Biology Laboratory, Raiganj University, Raiganj, India."},{"name":"Department of Zoology, Raiganj University, Raiganj, 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