{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:39:53Z","timestamp":1792312793144,"version":"4.4.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"abstract":"<jats:p>\n                    Renal cell carcinoma (RCC) exhibits extensive metabolic reprogramming and tumor microenvironmental heterogeneity, contributing to variable outcomes and treatment responses.\n                    <jats:italic toggle=\"yes\">Hydroxyacid oxidase 2 (HAO2)<\/jats:italic>\n                    has been implicated in metabolic regulation, but its clinical and biological relevance in RCC remains incompletely characterized. We integrated transcriptomic, proteomic, genomic, and single-cell RNA-sequencing data to characterize\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression, clinicopathological associations, metabolic and immune features, and treatment-related outcomes. Exploratory drug-sensitivity associations were evaluated using the Genomics of Drug Sensitivity in Cancer database and pRRophetic.\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression was consistently reduced across multiple RCC datasets and showed tumor\u2013normal discrimination with area under the curves ranging from 0.73 to 0.97. Low\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression was associated with advanced stage and shorter overall survival.\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression was positively associated with metabolic programs and distinct immune microenvironmental features. In the CheckMate-025 cohort, higher\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression was associated with longer overall survival in both treatment arms. Single-cell analysis showed reduced\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression in malignant renal epithelial cells. Exploratory pharmacogenomic analysis identified associations between\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    expression and drug sensitivity.\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    downregulation is associated with advanced disease, unfavorable survival, and distinct metabolic and immune features in RCC.\n                    <jats:italic toggle=\"yes\">HAO2<\/jats:italic>\n                    represents a candidate tissue-associated biomarker warranting further experimental and prospective validation.\n                  <\/jats:p>","DOI":"10.1177\/15578100261495845","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:54:14Z","timestamp":1792133654000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiomics Characterization of\n                    <i>HAO2<\/i>\n                    Expression and Its Clinical Associations in Clear Cell Renal Cell Carcinoma"],"prefix":"10.1177","author":[{"given":"Haiting","family":"Chen","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Yancheng No. 1 People\u2019s Hospital, Yancheng, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostic Technology Co., Ltd., Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neurology and Oncology Drug Development, Nanjing Simcere Medical Laboratory Science Co., Ltd., Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostic Technology Co., Ltd., Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostic Technology Co., Ltd., Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostic Technology Co., Ltd., Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5244-4303","authenticated-orcid":false,"given":"Weigang","family":"Bian","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Yancheng No. 1 People\u2019s Hospital, Yancheng, 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