{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:47:40Z","timestamp":1791830860379,"version":"4.3.4"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"abstract":"<jats:p>\n                    Mismatch repair-proficient or microsatellite stable (MMRp\/MSS) endometrial cancer derives limited benefit from immune checkpoint inhibitor monotherapy, and immune exclusion may reflect both barrier-like tumor-stromal programs and insufficient T cell\/natural killer cell (T\/NK-cell) effector activity. We integrated The Cancer Genome Atlas uterine corpus endometrial carcinoma (TCGA-UCEC), Clinical Proteomic Tumor Analysis Consortium (CPTAC)-UCEC, GSE17025, GSE21882, and GSE251923 to derive and evaluate an immune exclusion index (IEI) in candidate MMRp\/MSS tumors. IEI was derived from a 112-gene biologically constrained candidate pool using Cox elastic-net modeling in the TCGA candidate MMRp\/MSS cohort (243 tumors, 39 death events). The weighted 9-gene IEI showed apparent association with poor overall survival in the same TCGA cohort (unadjusted hazard ratio [HR] = 5.06, 95% confidence interval [CI] 2.80\u20139.14,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 7.77e-08; adjusted HR = 2.00, 95% CI 1.37\u20132.93,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 3.62e-04). Median stratification gave HR = 8.15. Gene Expression Omnibus cohorts supported the adverse phenotype direction but not independent MMRp\/MSS survival validation; CPTAC and GSE251923 supported RNA-protein and spot-level marker consistency. IEI provides an interpretable framework for candidate T\/NK-low, barrier-like microenvironmental states.\n                  <\/jats:p>","DOI":"10.1177\/15578100261495854","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:43:10Z","timestamp":1791542590000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An Immune Exclusion Index Identifies T\/NK Cell Effector Deficiency and a Barrier-Like Microenvironmental State in MMRp\/MSS Endometrial Cancer"],"prefix":"10.1177","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0137-2898","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Duan","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunming","family":"Li","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingya","family":"Li","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Jia","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine, Tenth People\u2019s Hospital of Tongji University, Shanghai, 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