{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:34:19Z","timestamp":1793122459025,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"abstract":"<jats:p>\n                    Public mucosal transcriptomic datasets provide an opportunity to examine whether experimental epithelial barrier biology is reflected in human inflammatory bowel disease (IBD) endpoints. We constructed a prespecified barrier-injury transcriptomic score from an inositol polyphosphate multikinase\u2013histone deacetylase 3\u2013matrix metalloproteinase (MMP) barrier-biology gene set and epithelial junctional genes, then evaluated it across 10 public IBD mucosal transcriptomic cohorts (2172 scored biopsies) and an independent prospective adult cohort (GSE193677; 1162 participants). Adult cohorts were analyzed for mucosal healing, clinical remission, or treatment response; pediatric and early onset cohorts were analyzed separately. In UNIFI (GSE206285), a higher baseline score was inversely associated with week 8 mucosal healing (odds ratio [OR]: 0.56, 95% confidence interval [CI]: 0.45\u20130.71,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). In GSE193677, the score was associated with IBD compared with control status (OR: 1.71, 95% CI: 1.45\u20132.02) and with endoscopic and histologic activity. The association was directionally consistent across biopsy-selection analyses and exceeded expression- and variance-matched random-gene estimates (empirical\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.034), while MMP and inflammatory comparators were at least as strong. Single-cell data localized the MMP module predominantly to stromal cells. These findings support retrospective transcriptomic stratification of mucosal injury states and define a barrier biology\u2013motivated bulk mucosal readout shaped by stromal inflammatory remodeling in human tissue.\n                  <\/jats:p>","DOI":"10.1177\/15578100261499489","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:51:41Z","timestamp":1792821101000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelial Barrier-Injury Transcriptomic Stratification Across Human IBD Mucosal Cohorts"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6221-9828","authenticated-orcid":false,"given":"Hongwei","family":"Zheng","sequence":"first","affiliation":[{"name":"Quanzhou Medical College, Quanzhou, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanping","family":"Bu","sequence":"additional","affiliation":[{"name":"Quanzhou Medical College, Quanzhou, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Quanzhou First Hospital, Quanzhou, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12687"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326451"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007984"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178665"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312293"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-68994-0"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0697"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32641-7"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40156-6"},{"key":"e_1_3_3_16_1","unstructured":"Gene Expression Omnibus. GSE214695: IBD single cell data from colonic mucosa. 2023. 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