{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:41:19Z","timestamp":1783651279603,"version":"3.55.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aimed to investigate health-related quality of life (HRQOL) and related factors in Hangzhou, China, in patients with non-alcoholic fatty liver disease (NAFLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The Chinese version of the EQ-5D-5L questionnaire was employed to assess HRQOL in 594 patients. A standardized questionnaire was employed to gather data regarding demographics, clinical characteristics, and lifestyle. This study employed Tobit regression models alongside multiple linear regression to examine the components influencing HRQOL, encompassing utility values and the EQ visual analogue scale (EQ-VAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This study included 594 participants with a mean age of 42.03 \u00b1 13.83 years. The median utility index was 0.951 (P25-P75: 0.934\u20131.000), and the median EQ-VAS score was 76 (P25-P75: 66\u201382). Anxiety and depression were the predominant entry (31.9%) among the five health dimensions. Tobit regression models indicated that retirement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.011), monthly income &gt;6000 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), alcohol consumption (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012), low-intensity activity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), obesity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004), and cirrhosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.038) were correlated with diminished HRQOL. The outcomes of multiple linear regression analyses indicated that regular exercise (\u03b2 = 3.200;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) and alcohol consumption (\u03b2 = 2.466;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.049) exhibited significant positive correlations with EQ-VAS scores, whereas obesity (\u03b2 = \u22124.259;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005) and severe hepatic steatosis (\u03b2 = \u22123.912;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.036) demonstrated significant negative correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The anxiety\/depression dimension was the most prevalent problem. The current investigation identified a notable correlation between HRQOL and low-intensity activity, obesity, and cirrhosis. Obesity and severe hepatic steatosis exhibited a substantial negative correlation with the EQ-VAS score. Future efforts should focus on enhancing the mental health and lifestyle of NAFLD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578518251363914","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:42:21Z","timestamp":1763530941000},"page":"329-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Health-Related Quality of Life and Its Influencing Factors Among Patients with Non-Alcoholic Fatty Liver Disease in Hangzhou, China: A Cross-Sectional Study"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5531-4221","authenticated-orcid":false,"given":"Han","family":"Fei","sequence":"first","affiliation":[{"name":"School of Nursing, Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Nursing, Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Nursing, Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Nursing, Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Quan","sequence":"additional","affiliation":[{"name":"School of Nursing, Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China."},{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Hangzhou, China."},{"name":"Institute of Hepatology and Metabolic Diseases, Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Teaching, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.62347\/KMSA5983"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0239"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.040"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31150"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1047129"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013620"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520250075037"},{"key":"e_1_3_8_12_2","unstructured":"China Pharmacoeconomics Evaluation Guide 2020. 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