{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:58:07Z","timestamp":1793757487182,"version":"4.6.1"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100020149","name":"Consejo Estatal de Ciencia y Tecnolog\u00eda de Jalisco","doi-asserted-by":"crossref","award":["FODECIJAL 8213-2019"],"award-info":[{"award-number":["FODECIJAL 8213-2019"]}],"id":[{"id":"10.13039\/100020149","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n Background:<\/jats:title>\n \n Variants in\n ADIPOQ<\/jats:italic>\n may affect gene expression and serum adiponectin levels (SAL), contributing to the development of metabolic syndrome (MetS) components and cardiometabolic disorders in Mexican adolescents.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n To evaluate the association of the genetic variants rs266729, rs822396, rs2241766, and rs1501299 in\n ADIPOQ<\/jats:italic>\n , their haplotypes, and SAL with MetS components and cardiometabolic parameters in adolescents from western Mexico.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A total of 494 adolescents from Jalisco, Mexico, aged 10\u201317 years, were studied. The biochemical and clinical characteristics of cardiometabolic disorders were diagnosed based on age-, sex-, and population-specific percentiles. Peripheral blood samples were obtained. Serum was separated and SAL were measured by ELISA. DNA was extracted and genotyped using real-time polymerase chain reaction for allelic discrimination. Hardy\u2013Weinberg equilibrium was assessed, and associations were analyzed using logistic regression and Spearman correlations, with a 95% statistical confidence level.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n SAL were lower in adolescents with MetS (\n P<\/jats:italic>\n = 0.03) and low high-density lipoprotein (\n P<\/jats:italic>\n = 0.01). The rs266729G allele was associated with very low-density lipoprotein >30 mg\/dL in the additive inheritance model [AIM; odds ratio (OR) = 1.59, 95% confidence interval (CI) = 1.01\u20132.53,\n P<\/jats:italic>\n = 0.04], dominant inheritance model (DIM; OR = 2.26, 95% CI = 1.07\u20134.73,\n P<\/jats:italic>\n = 0.03), and codominant inheritance model (OR = 2.23, 95% CI = 1.03\u20134.81,\n P<\/jats:italic>\n = 0.04). The rs822396G allele was associated with decreased SAL in AIM (OR = 5.00, 95% CI = 1.69\u201314.7,\n P<\/jats:italic>\n = 0.004) and DIM (OR = 5.23, 95% CI = 1.41\u201321.6,\n P<\/jats:italic>\n = 0.01). The rs2241766G allele (recessive model) was associated with increased alanine aminotransferase levels (OR = 3.73, 95% CI = 1.10\u201312.6,\n P<\/jats:italic>\n = 0.03) and correlated with higher SAL (\n R<\/jats:italic>\n = 0.202,\n P<\/jats:italic>\n = 0.045). In controls, the haplotype rs822396\u2013rs2241766\u2013rs1501299 is in linkage disequilibrium (\n D<\/jats:italic>\n \u2032 = 1), but the correlation is low (\n R<\/jats:italic>\n 2<\/jats:sup>\n < 0.1), while in MetS adolescents,\n D<\/jats:italic>\n \u2032 was incomplete. Several haplotypes were associated with cardiometabolic parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The variants in\n ADIPOQ<\/jats:italic>\n , are associated with MetS and low SAL. The rs822396G allele appears to be a key factor for low SAL and its association with cardiometabolic parameters. The rs2241766T allele was linked to low SAL and clinical characteristics of MetS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/15578518251389898","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:32:26Z","timestamp":1761355946000},"page":"34-47","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Variants and Haplotypes in\n ADIPOQ<\/i>\n , and Serum Adiponectin Levels with Metabolic Syndrome and Its Components in Mexican Adolescents"],"prefix":"10.1177","volume":"24","author":[{"given":"Diego","family":"Ortega-Pacheco","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Carlos","family":"Rosales-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Jalisco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Arcelia","family":"Garc\u00eda-Cobi\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia Ariadna","family":"Rubio-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Departamento de Gesti\u00f3n para la Sostenibilidad Centro Universitario de Guadalajara, Universidad de Guadalajara, Jalisco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Adriana","family":"Guti\u00e9rrez-Rubio","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Hospital de Ginecolog\u00eda y obstetricia UMAE 23, Instituto Mexicano del Seguro Social Nuevo Le\u00f3n, Monterrey, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Hugo","family":"Rivera-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Urgencias, Hospital General de Zona 2, Instituto Mexicano del Seguro Social, Nuevo Le\u00f3n, Monterrey, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de la Luz","family":"Ayala-Madrigal","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Instituto de Gen\u00e9tica Humana \u201cDr Enrique Corona Rivera\u201d, Gen\u00f3mica Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-3926","authenticated-orcid":false,"given":"Susan Andrea","family":"Guti\u00e9rrez-Rubio","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Organizaci\u00f3n Mundial de la Salud. 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