{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:32Z","timestamp":1788265472379,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with severe mental disorders (SMD) are at substantially elevated risk for metabolic syndrome (MetS), contributing to excess cardiovascular morbidity and premature mortality. Adverse childhood experiences (ACEs) have been associated with dysregulation of metabolic pathways, yet their contribution to MetS risk in SMD remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between ACEs and MetS in outpatients with bipolar disorder (BD) and schizophrenia (SZ) in clinical remission and to identify independent and incremental predictors of MetS using a hierarchical analytical framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study included 140 outpatients with SMD (96 with BD and 44 with SZ) in clinical remission, recruited from a university hospital in Eastern Turkey. MetS was defined according to NCEP-ATP III criteria, and ACEs were assessed using the Turkish version of the Adverse Childhood Experiences Scale (ACE-TR). Hierarchical and multivariable logistic regression analyses were performed to examine factors associated with MetS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      MetS was highly prevalent in this sample (46.4%). ACE-TR total score was independently and consistently associated with MetS across all hierarchical models (odds ratio [OR] range: 1.68\u20131.77), with each one-unit increase conferring approximately 71% higher odds in the fully adjusted model (OR = 1.71; 95% confidence interval [CI] 1.26\u20132.32;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). The number of hospitalizations was the only other independently associated variable (OR = 1.19; 95% CI 1.02\u20131.39). Sexual abuse (16.9% vs. 2.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004), emotional neglect (63.1% vs. 30.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and physical neglect (30.8% vs. 14.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.022) were significantly more prevalent in the MetS group. ACE-TR total score was positively correlated with waist circumference and triglyceride levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The strong and consistent association between ACEs and MetS underscores the importance of trauma-informed care models in psychiatric practice, where metabolic comorbidity remains a leading cause of premature mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578518261451959","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:17:43Z","timestamp":1779373063000},"page":"335-342","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Are Adverse Childhood Experiences Associated with Metabolic Syndrome in Patients with Severe Mental Illness?"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-205X","authenticated-orcid":false,"given":"Neslihan","family":"Cansel","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9526-4314","authenticated-orcid":false,"given":"Merve","family":"\u00c7elik \u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eahide Nur \u0130pek","family":"Melez","sequence":"additional","affiliation":[{"name":"Department of \u0130nternal Medicine, Gaziantep City Hospital, Gaziantep, T\u00fcrkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-3393","authenticated-orcid":false,"given":"\u015eeyma","family":"Ya\u015far","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.8"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx056"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102294"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020786"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0812-z"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12050620"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr148"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2025.13479"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnu.2025.151942"},{"key":"e_1_3_4_11_1","volume-title":"Preventing adverse childhood experiences: Leveraging the best available evidence","author":"Prevention CfDCa","year":"2019","unstructured":"10.Prevention CfDCa. Preventing adverse childhood experiences: Leveraging the best available evidence. National Center for Injury Prevention and Control, Centers for Disease Control and Prevention: Atlanta, GA; 2019."},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6844e1"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.54"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01612840.2016.1224281"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00823.x"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3048"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S460058"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000536"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-3797(98)00017-8"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.5455\/apd.294158"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.70095"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291723003264"},{"key":"e_1_3_4_24_1","volume-title":"Child Sexual Abuse. StatPearls","author":"Daley SF","year":"2025","unstructured":"23.Daley SF, , Gutovitz S. Child Sexual Abuse. StatPearls. StatPearls Publishing: Treasure Island (FL); 2025."},{"key":"e_1_3_4_25_1","first-page":"95","article-title":"\u00c7ocukluk \u00e7a\u011f\u0131 cinsel istismar\u0131","volume":"1","author":"Aktepe E","year":"2009","unstructured":"24.Aktepe E. \u00c7ocukluk \u00e7a\u011f\u0131 cinsel istismar\u0131. Psikiyatride G\u00fcncel Yakla\u015f\u0131mlar 2009;1:95\u2013119.","journal-title":"Psikiyatride G\u00fcncel Yakla\u015f\u0131mlar"},{"key":"e_1_3_4_26_1","first-page":"21","article-title":"Travma sonras\u0131 zaman\u0131n donmas\u0131 ve travman\u0131n nesiller aras\u0131 aktar\u0131m\u0131","volume":"3","author":"Yal\u00e7\u0131n \u00c7PS","year":"2018","unstructured":"25.Yal\u00e7\u0131n \u00c7PS, , \u00d6zt\u00fcrk E. Travma sonras\u0131 zaman\u0131n donmas\u0131 ve travman\u0131n nesiller aras\u0131 aktar\u0131m\u0131. Bart\u0131n \u00dcniversitesi Edebiyat Fak\u00fcltesi Dergisi 2018;3:21\u201328.","journal-title":"Bart\u0131n \u00dcniversitesi Edebiyat Fak\u00fcltesi Dergisi"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.5455\/annalsmedres.2019.12.829"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01756.x"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08353"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/532082"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.39.4.f"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2010.07.004"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-017-0779-9"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.988695"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21122"}],"container-title":["Metabolic Syndrome and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15578518261451959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15578518261451959","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15578518261451959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:04:16Z","timestamp":1788264256000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15578518261451959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1177\/15578518261451959"],"URL":"https:\/\/doi.org\/10.1177\/15578518261451959","relation":{},"ISSN":["1540-4196","1557-8518"],"issn-type":[{"value":"1540-4196","type":"print"},{"value":"1557-8518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}