{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:26:40Z","timestamp":1793748400361,"version":"4.6.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Syndrome and Related Disorders"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Obesity is defined as the accumulation of dysfunctional adipose tissue, accompanied by metabolic and immunological disturbances that increase the risk of organ damage. Current definitions recommend the waist-to-height ratio (WHtR) as a practical indicator of central adiposity, while immunometabolic biomarkers may improve early risk stratification. The present study evaluated whether immunometabolic indices derived from routine hematological and lipid parameters can differentiate WHtR categories and identify young adults with elevated cardiometabolic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted with 1296 volunteers aged 18\u201326 years, from the university health center at the Autonomous University of San Luis Potosi, Mexico. Participants were classified according to WHtR as WHtR &lt; 0.5, WHtR 0.50\u20130.59, and WHtR \u2265 0.60. The indices calculated were low-density lipoprotein cholesterol (LDL-c)\/high-density lipoprotein cholesterol (HDL-c), red cell distribution width (RDW)\/HDL-c, RDW\/TAG, uric acid-to-HDL-c ratio (UHR), monocyte-to-HDL-c ratio (MHR), and aggregate index of systemic inflammation (AISI). Multivariate analyses were used for exploration, variable selection, and construction of an immunometabolic score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Participants with WHtR \u2265 0.60 represented 10.9% of the cohort and demonstrated higher triglycerides, LDL-c, uric acid, UHR, and MHR, which showed positive correlations with body mass index and blood pressure. UHR demonstrated 85.1% sensitivity and 65.5% specificity in discriminating WHtR \u2265 0.60. A least absolute shrinkage and selection operator-derived immunometabolic score, incorporating LDL-c-to-HDL-c, RDW-to-TAG, UHR, AISI, and sex, increased across WHtR categories and discriminated WHtR \u2265 0.60 with an area under the curve of 0.869.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings support the potential use of these immunometabolic indices as complementary tools for identifying young adults with a higher cardiometabolic risk profile and high central adiposity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578518261490095","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:58:02Z","timestamp":1789984682000},"page":"456-466","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunometabolic Score AISI, UHR, RDW-to-Triglycerides and LDL-c-to-HDL-c Ratios as Early Markers of Cardiometabolic Risk in a Young Mexican Population with Elevated Waist-to-Height Ratio"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6427-6615","authenticated-orcid":false,"given":"Rub\u00e9n Omar","family":"Urbina-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosi (UASLP), San Luis Potosi, M\u00e9xico."},{"name":"Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Diego","family":"Cort\u00e9s-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eneida","family":"Turij\u00e1n-Espinoza","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isela","family":"Parra-Rojas","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Research Laboratory, Faculty of Chemical and Biological Sciences, Autonomous University of Guerrero, Guerrero, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alfredo","family":"Haro-Ort\u00edz","sequence":"additional","affiliation":[{"name":"University Health Center, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Lares-Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Clinical Analysis Laboratory, Dr. Pedro Medina de los Santos, Faculty of Chemical Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Vargas-Morales","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."},{"name":"Clinical Analysis Laboratory, Dr. Pedro Medina de los Santos, Faculty of Chemical Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potosi, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-7869","authenticated-orcid":false,"given":"Diana 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