{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:11:28Z","timestamp":1777943488142,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korean Academy of Rehabilitation Medicine","award":["Chung Hie Oh & Jin-Sang Chung Research Grant 2018"],"award-info":[{"award-number":["Chung Hie Oh & Jin-Sang Chung Research Grant 2018"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lymphedema is a common but distressing sequela after cancer treatment. A cure is not yet available; thus, prevention is essential in its management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Here, we used a mouse hindlimb model to demonstrate the effects of exercise performed before lymph node resection and irradiation on the development of lymphedema. BALB\/c mice trained on a treadmill at moderate intensity, 30 minutes\/day, 5 times\/week for 4 weeks, were compared to a no-exercise group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7\/group). Weekly limb measurements and indocyanine green (ICG) lymphangiography were performed to assess lymphedema severity. Pre-injury exercise mice consistently showed a lower percentage excess in ankle diameter, reflecting a lesser degree of swelling. Moreover, most of them exhibited the mild \u201csplash\u201d pattern on ICG lymphangiography, while some reverted to the normal linear pattern on the 3rd week. Meanwhile, most of the no-exercise mice displayed the moderate \u201cstardust\u201d and severe \u201cdiffuse\u201d patterns throughout the observation period. Histopathological analysis revealed a lesser increase in skin thickness and a greater density of lymphatic vessels of the exercise mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Taken together, results showed that pre-injury exercise attenuated the development of lymphedema in our mouse hindlimb model. This provides preliminary evidence on the potential preventive role of exercise in secondary lymphedema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578585251387097","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:59:33Z","timestamp":1762649973000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre-Injury Exercise Attenuates Lymphedema Induced by Surgery and Radiation in a Mouse Hindlimb Model"],"prefix":"10.1177","volume":"24","author":[{"given":"Ma Nessa","family":"Gelvosa","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwayeong","family":"Cheon","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hwa","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jae","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Suk Peter","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072546"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3201"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25458"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.06.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30508"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007783"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31829b4afe"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2458\/lymph.4655"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2009.01.001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1837"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.09.012"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9098(200006)74:2<95::AID-JSO3>3.0.CO;2-Q"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005091"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72351"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2017.24.5.11"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/jp271757"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01687"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04635.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0072"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31820cf5df"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0033"},{"issue":"4","key":"e_1_3_3_24_2","first-page":"7565","article-title":"A refined mouse hind limb model of secondary lymphedema","volume":"9","author":"Dai TT","year":"2016","unstructured":"Dai TT, , Cui CX, , Cao WG, et al. A refined mouse hind limb model of secondary lymphedema. 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