{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:09:34Z","timestamp":1779358174729,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"crossref","award":["22 2064 Pj 01H."],"award-info":[{"award-number":["22 2064 Pj 01H."]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early diagnosis and treatment of breast cancer-related arm lymphedema (BCRAL) is essential to prevent progression. Local tissue water (LTW) can be assessed using the tissue dielectric constant (TDC), enabling detection before an increase of arm volume occurs. However, knowledge of the variation of LTW during cancer treatment and appropriate LTW thresholds for early detection of BCRAL is limited. The aim of this study was to examine differences in LTW between the arms, assess changes in LTW in each arm during adjuvant treatment, and calculate theoretical inter-arm thresholds for BCRAL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and Results:<\/jats:title>\n                    <jats:p>This retrospective cohort study included 120 women treated with axillary lymph node dissection and radiotherapy. At 4\u20136 weeks post-surgery, LTW was significantly higher in the contralateral upper arm and the forearm at the lateral site compared to the ipsilateral arm. At 3\u20134 months post-radiotherapy, LTW remained higher in the contralateral upper arm at the lateral site and the forearm at the medial site. LTW decreased at the medial site of the ipsilateral upper arm and at the ventral site of the contralateral upper arm. Potential TDC ratio thresholds to detect BCRAL, including 3 SD, were calculated as 1.40 in the upper arm and 1.30 in the forearm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>At both follow-ups, LTW was higher in the contralateral arm at specific sites compared to the ipsilateral arm and decreased at specific sites in both arms during oncological treatment. The calculated TDC thresholds may improve detection of BCRAL and enhance the interpretation of lymphedema status during oncological treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578585261419366","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:49:06Z","timestamp":1770274146000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Tissue Water Variations in Women at Risk of Developing Arm Lymphedema Following Breast Cancer Treatment\u2014A Retrospective Study"],"prefix":"10.1177","volume":"24","author":[{"given":"Katarina","family":"Blom","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden."},{"name":"Physiotherapy Cancer, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Brog\u00e5rdh","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden."},{"name":"Department of Neurology, Rehabilitation Medicine, Memory Disorders and Geriatrics, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Nilsson-Wikmar","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Huddinge, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Sackey","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden."},{"name":"Division of Cancer, Department of Breast, Endocrine Tumors and Sarcoma, Karolinska Comprehensive Cancer Centre, Karolinska University Hospital, Solna, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061774"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020138"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(13)70076-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.04.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005671"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/0284186x.2022.2081932"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2014.0035"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00197"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6601-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3993-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-012-0247-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2022.0020"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30090585"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12541"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2011.07.021"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2019.0042"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4185-5"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0008"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/14038190119371"},{"issue":"2","key":"e_1_3_3_22_2","first-page":"15","article-title":"Tissue Dielectric Constant (TDC) as an index of localized arm skin water: Differences between measuring probes and genders","volume":"52","author":"Mayrovitz HN","year":"2015","unstructured":"Mayrovitz HN, , Arzanova E, , Somarriba S, et al. Tissue Dielectric Constant (TDC) as an index of localized arm skin water: Differences between measuring probes and genders. 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