{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:40:48Z","timestamp":1791409248578,"version":"4.3.3"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aim:<\/jats:title>\n                    <jats:p>Although various distinctive morphological features such as hyperproliferation of adipocytes, fibrosis, and inflammation have been described in the progression of lipedema, the underlying mechanisms of these changes are not yet fully understood. In this study, we aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) to demonstrate the role of inflammation in lipedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The retrospective study consisted of 60 lipedema patients (Group 1) and 40 healthy controls (Group 2). The age, height, weight, and body mass index (BMI) of all participants were recorded, along with the lipedema type and stage for Group 1. Laboratory results, including complete blood count, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were obtained for all participants. Hemoglobin, leukocyte, lymphocyte, neutrophil, and platelet counts, NLR, PLR, MPV, PDW, CRP, and ESR were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age was 45.45 \u00b1 10.17 years in Group 1 and 44.90 \u00b1 10.69 years in Group 2; the BMI was 32.15 \u00b1 5.05 in Group 1 and 30.94 \u00b1 4.98 in Group 2, with no significant difference between the groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). The most common type was Type 2 lipedema. Platelet counts, CRP, NLR, and PLR levels were significantly higher in Group 1 than in Group 2 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). There was no difference between groups in MPV and PDW values (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). There was a positive correlation between BMI and both leukocyte count and CRP levels (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In our study investigating inflammation in lipedema\u2014an etiology that is still not fully understood\u2014NLR, PLR, platelet count, and CRP levels were found to be significantly higher in the patient group. The increase in BMI was correlated with leukocyte count and CRP levels. This finding is important for elucidating the etiopathogenesis of the disease, and we believe it may guide future research in this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578585261454779","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:00:36Z","timestamp":1780992036000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory Markers in Lipedema: A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume"],"prefix":"10.1177","volume":"24","author":[{"given":"Ayla","family":"Cagliyan Turk","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hitit University, Corum, T\u00fcrkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ender","family":"Erden","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hitit University, Corum, T\u00fcrkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Borman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Ankara City Hospital, University of Health Sciences, Ankara, T\u00fcrkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09413.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1080-x"},{"key":"e_1_3_2_4_2","first-page":"395","volume-title":"Textbook of Lymphology","author":"F\u00f6ldi E","year":"2003","unstructured":"F\u00f6ldi E, , F\u00f6ldi M, , F\u00f6ldi M, et al. Lipoedema. Ineds. Textbook of Lymphology. Urban and Fischer, Jena, Germany; 2003: 395\u2013403."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126621"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1223264"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.10.009"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8747461"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-01002-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12281"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.08.003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.12.159"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6036979"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13037"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13404"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/185317"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3647-0"},{"key":"e_1_3_2_18_2","first-page":"17","volume-title":"Lipedema","author":"Ayhan FF","year":"2019","unstructured":"Ayhan FF. Lipedema: Clinical diagnosis, staging, typing, evaluation and diagnostic criteria. In: Lipedema. (Borman P, , Dalyan M, , Ayhan FF. eds.) Hipokrat: Ankara; 2019; pp. 17\u201334."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123081"},{"issue":"2","key":"e_1_3_2_20_2","first-page":"71","article-title":"Lipedema is associated with increased aortic stiffness","volume":"45","author":"Szolnoky G","year":"2012","unstructured":"Szolnoky G, , Nemes A, , Gavall\u00e9r H, et al. Lipedema is associated with increased aortic stiffness. 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Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia, 2010; 14(1):28\u201332.","journal-title":"Hippokratia"},{"key":"e_1_3_2_33_2","first-page":"1751","article-title":"Parameters of total blood count; might they be indicators of Accepted Manuscript inflammation in rheumatoid arthritis and ankylosing spondylitis","volume":"34","author":"Illeez O","year":"2018","unstructured":"Illeez O, , Ozkan FU, , Aktas I. Parameters of total blood count; might they be indicators of Accepted Manuscript inflammation in rheumatoid arthritis and ankylosing spondylitis? 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