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Notably, there are several similarities between lymphedema and Alzheimer\u2019s disease (AD). Accumulating evidence suggests that lymphedema might be associated with AD, potentially influencing its progression through mechanisms related to the peripheral\u2013central lymphatic circulation. This review summarizes the lymphatic system\u2019s structure, function, and drainage pathways, emphasizing how aging and blockage of the CLS can exacerbate the progression of AD. Additionally, we discuss the relationship between lymphedema and AD, highlighting the significance of the PLS\u2013CLS and exploring lymphaticovenous anastomosis as a promising treatment for both lymphedema and AD.<\/jats:p>","DOI":"10.1177\/15578585261471251","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:09:45Z","timestamp":1785913785000},"page":"239-247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphedema and Alzheimer\u2019s Disease: Connecting Through the \u201cPeripheral\u2013Central Lymphatic System\u201d"],"prefix":"10.1177","volume":"24","author":[{"given":"Xinxin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Metabolism, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China."},{"name":"Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongKai","family":"Lian","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Metabolism, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China."},{"name":"Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2021"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322867"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221098145"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0368-8"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1233908"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0072-5"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01565"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2020"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00500-9"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225017622"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15697"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00001.x"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0619-21.2021"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.844938"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1138769"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00852.2019"},{"key":"e_1_3_3_21_1","article-title":"Lymphatic vessel: Origin, heterogeneity, biological functions, and therapeutic targets","volume":"3","author":"Hu Z","year":"2024","unstructured":"20.Hu Z, , Zhao X, , Wu Z, et al. 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