{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:44:27Z","timestamp":1792075467675,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Key R&D Program of China","award":["2023YFC2706005"],"award-info":[{"award-number":["2023YFC2706005"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lymphatic Research and Biology"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The primary aim of this retrospective cohort study was to explore the incidence and independent risk factors of chylous leak after laparoscopic surgery for gynecological malignancies. The secondary aims included quantifying the adverse clinical impacts of chylous leakage on postoperative recovery indicators, summarizing standardized conservative treatment regimens and curative effects of chylous leak patients, and providing intraoperative preventive suggestions for clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data on 495 patients who underwent surgery for gynecologic malignancies in the Department of Gynecology, the Second Hospital of Shandong University from January 2018 to April 2022 were collected. The risk factors related to the occurrence of chylous leak were then analyzed statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 394 patients underwent laparoscopic surgery and were divided into 2 groups according to the occurrence of chylous leak after surgery: 19 patients were in the case group, and 375 patients were in the control group. The incidence of chylous leak in this study was 4.82%. Univariate analysis showed preoperative anemia (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.01) and enlarged lymph nodes (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.008) as risk factors for chylous leak. Statistical analysis of postoperative factors between the two groups showed significantly increased length of hospitalization (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \uff1d 0.001) and hospitalization costs (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.003), postoperative maximum temperature (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) maximum drain output (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), and drainage tube days (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) in the case group compared with the control group. Multivariate binary logistic regression analysis showed that preoperative anemia (OR = 3.111, 95% CI = 1.081\u20138.953) was the risk factor for chylous leak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The occurrence of chylous leak after laparoscopic surgery for gynecological malignancies leads to prolonged hospital stay, increased medical costs. The possibility of chylous leak occurring after laparoscopic surgery for gynecological malignancies with preoperative anemia is high.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578585261497879","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:23:57Z","timestamp":1791872637000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors and Impact of Chylous Leak after Laparoscopic Surgery for Gynecological Malignancies"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-5450","authenticated-orcid":false,"given":"Ya","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Qilu Hospital of Shandong University, Jinan, 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