{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:03:00Z","timestamp":1784552580522,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Swiss National Science Foundation, Switzerland","award":["P2ZHP3_168561"],"award-info":[{"award-number":["P2ZHP3_168561"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Strunz, Patrick-Pascal, Raphael N. Vuille-dit-Bille, Heiko Fruehauf, Mark Fox, Andreas Geier, Marco Maggiorini, Max Gassmann, Thomas A. Lutz, and Oliver Goetze. Acute high-altitude exposure increases transcription of tricarboxylic acid cycle enzymes in human duodenal biopsies.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 27:184\u2013188, 2026.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      A recent study of our group quantifying\n                      <jats:sup>13<\/jats:sup>\n                      C-octanoate metabolism in HA (Capanna Margherita [MG]\/4,559 m) showed that acute HA exposure might lead to an increase of the lipolytic and CO\n                      <jats:sub>2<\/jats:sub>\n                      -producing pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To further test this hypothesis, we investigated intestinal biopsies from the same participants from simultaneously performed endoscopy studies for changes of mRNA-expression levels of the beta-oxidation enzymes and the decarboxylating tricarboxylic acid cycle (TCA) enzymes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Duodenal biopsies of 16 subjects exposed to HA were sampled via gastro-duodenoscopy at Zurich (baseline ZH, 490 m), on day 2 (MG2) and on day 4 at HA (MG4). After mRNA extraction, quantitative real-time polymerase chain reaction was performed to assess mRNAs expression of TCA cycle enzymes as well as beta-oxidation enzymes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Aconitase mRNA levels increased early (MG2 vs. ZH,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05) and were still higher at day 4 compared with ZH (MG4 vs. ZH,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Isocitrate dehydrogenase (DH) levels increased with time spent at 4,559 m (MG4 vs. ZH,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). The remaining TCA cycle and beta-oxidation enzymes investigated tended to higher values at HA but without reaching significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We conclude that acute exposure to HA leads to increased transcription of aconitase and isocitrate DH in the duodenal mucosa due to hypobaric hypoxia exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578682251374980","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T18:27:09Z","timestamp":1759256829000},"page":"184-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute High-Altitude Exposure Increases Transcription of Tricarboxylic Acid Cycle Enzymes in Human Duodenal Biopsies"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3168-7074","authenticated-orcid":false,"given":"Patrick-Pascal","family":"Strunz","sequence":"first","affiliation":[{"name":"Rheumatology\/Clinical Immunology, Department of Medicine II, University Hospital Wurzburg, Wuerzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael N.","family":"Vuille-dit-Bille","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, University Children\u2019s Hospital of Basel, Canton Basel Stadt, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Fruehauf","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland."},{"name":"Digestive Function: Basel, Laboratory and Clinic for Motility Disorders and Functional Digestive Diseases, Klinik Arlesheim, Arlesheim, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Geier","sequence":"additional","affiliation":[{"name":"Hepatology, Department of Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Maggiorini","sequence":"additional","affiliation":[{"name":"Institute of Intensive Care, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2750-8878","authenticated-orcid":false,"given":"Max","family":"Gassmann","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology, 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