{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:30:12Z","timestamp":1787909412949,"version":"build-2784847793"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Marzola, Manuel, Massimiliano Marazzato, Roberto Nutini, Adriano Di Marzio, Francesca Baroli, Manuel Paolucci, Matteo De Angelis, Joanna Giuliano, Ambra Menichelli, Guglielmo Sferrati, Carmen Santangelo, Danilo Bondi, Gerardo Bosco, and Vittore Verratti. Effects of OXXYSLAB probiotic supplementation on blood oxygenation and hypoxic symptoms in healthy individuals: A controlled normobaric hypoxia trial.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                    27:168\u2013176, 2026.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      OXXYSLAB, a high-dose, multi-strain probiotic, has shown promise in pathological hypoxemia but remains untested under acute normobaric hypoxia (NH) in healthy volunteers. We evaluated whether OXXYSLAB alters peripheral oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) and alleviates hypoxia-related symptoms in healthy adults exposed to NH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In two randomized, double-blind, crossover phases, young adults were exposed to \u223c13.5% inspired O\n                      <jats:sub>2<\/jats:sub>\n                      for 1 hour (Phase 1:\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12, 21.6 \u00b1 1.3 years, body mass index [BMI] = 23.2 \u00b1 2.8 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) or 40 minutes (Phase 2:\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20, 21.7 \u00b1 1.5 years, BMI = 22.9 \u00b1 3.2 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Participants received either a single (8 \u00d7 10\n                      <jats:sup>11<\/jats:sup>\n                      colony-forming unit [CFU]) or double (1.6 \u00d7 10\n                      <jats:sup>12<\/jats:sup>\n                      CFU) dose of OXXYSLAB or matched placebo in randomized order.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      NH induced the expected SpO\n                      <jats:sub>2<\/jats:sub>\n                      decrease (Phase 1: 90.0 \u00b1 2.1%; Phase 2: 86.7 \u00b1 2.9%), with no significant effect of probiotic supplementation on SpO\n                      <jats:sub>2<\/jats:sub>\n                      . In Phase 1, a trend toward lower heart rate (\u0394 = \u20133.2 bpm) under OXXYSLAB approached significance (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.053); no effect was seen in Phase 2. Notably, headache incidence under probiotic conditions was reduced by 50% (Phase 1) and 62.5% (Phase 2) compared to placebo (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.046 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.059, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While OXXYSLAB did not enhance systemic oxygenation during acute NH, it significantly attenuated headache, a common symptom of hypoxia. Further research should assess its efficacy under prolonged or clinical hypoxemic conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578682261415833","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:07:34Z","timestamp":1769159254000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of OXXYSLAB Probiotic Supplementation on Blood Oxygenation and Hypoxic Symptoms in Healthy Individuals: A Controlled Normobaric Hypoxia Trial"],"prefix":"10.1177","volume":"27","author":[{"given":"Manuel","family":"Marzola","sequence":"first","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Marazzato","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Nutini","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Di Marzio","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Baroli","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Paolucci","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"De Angelis","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Giuliano","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Menichelli","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, 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