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Erythrocytapheresis Improves Health-Related Quality of Life in High-Altitude Migrans with Chronic Mountain Sickness: A Single-Arm Before\u2013After Trial at 4,000\u20134,500 m.\n                      <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                      00:00\u201300, 2026.\n                    <\/jats:p>\n                    <jats:p>\n                      Chronic mountain sickness (CMS) arises from maladaptive responses to prolonged residence at altitudes exceeding 2,500 m. Despite the known efficacy of erythrocytapheresis on CMS, the impact of this intervention on health-related quality of life for individuals diagnosed with CMS remains poorly understood. We conducted a single-arm before\u2013after trial using erythrocytapheresis on a total of 22 male migrants with CMS who had resided at high altitudes (4,000\u20134,500 m) for 6.5 (3.8, 9.3) years. Participants underwent between 1 and 4 erythrocytapheresis sessions, with 1\u20132 days between each one. The participants exhibited significant improvements following the intervention: health-related quality of life score increased from 85.0 (80.0, 85.3) to 90.0 (90.0, 94.3) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001, d = 0.57); CMS score decreased from 7.0 (6.0, 8.0) to 3.0 (2.8, 4.0) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001, d = 0.62); the distance in the 6-Minute Walk Test improved from 612.5 (598.8, 623.0) meters to 654.0 (636.3, 676.3) meters (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001, d = 0.62); and SpO\n                      <jats:sub>2<\/jats:sub>\n                      levels rose from 87.5 (85.8, 90.0) to 90.0 (87.0, 92.5) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.012, d = 0.38). Erythrocytapheresis proves to be an effective intervention for enhancing health-related quality of life and reducing the severity of CMS in migrant populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578682261466533","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:22:31Z","timestamp":1783070551000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Erythrocytapheresis Improves Health-Related Quality of Life in High-Altitude Migrants\u00a0with Chronic Mountain Sickness: A Single-Arm Before\u2013After Trial at 4,000\u20134,500 m"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3319-6631","authenticated-orcid":false,"given":"Weiwei","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianli","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China."},{"name":"Department of Respiratory Disease, Nayong Volumey People\u2019s Hospital, Guizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Daping Hospital, Third Military Medical University and the Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianba","family":"Duojie","sequence":"additional","affiliation":[{"name":"Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Tibet, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Tibet, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Tibet, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China."},{"name":"Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Tibet, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.054544"},{"issue":"2","key":"e_1_3_3_3_1","first-page":"1","article-title":"The surgeon general\u2019s 1989 Report on reducing the health consequences of smoking: 25 Years of progress","volume":"38","author":"CDC CfDC","year":"1989","unstructured":"CDC CfDC. 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