{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:35Z","timestamp":1792787735977,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science and Technology Projects of Xizang Autonomous Region, China","award":["XZ202501JD0021"],"award-info":[{"award-number":["XZ202501JD0021"]}]},{"name":"Group-based Medical Aid Program for Xizang, Xizang Autonomous Region Natural Science Foundation","award":["XZ202601ZR0147, XZZR202402125(W)"],"award-info":[{"award-number":["XZ202601ZR0147, XZZR202402125(W)"]}]},{"name":"National Key Research and Development Program of China","award":["2024YFA0918504"],"award-info":[{"award-number":["2024YFA0918504"]}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2024-RW320-01"],"award-info":[{"award-number":["2024-RW320-01"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Chen, Chen, Yang, Li, Xu, Fan, Xu, Zhijuan Liu, and Dong Wu. Distinct etiological and clinical patterns of acute mesenteric ischemia at high altitude: a retrospective comparative study.\n                      <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                      00:00\u201300, 2026.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute mesenteric ischemia (AMI) is a life-threatening abdominal emergency, yet evidence regarding its etiology and clinical outcomes in high-altitude populations remains limited. This study aimed to compare the etiology, clinical characteristics, and outcomes of AMI between high- and low-altitude populations in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective comparative study at two tertiary referral centers in China: People\u2019s Hospital of the Xizang Autonomous Region (PHOXAR; 3,700 m) and Peking Union Medical College Hospital (PUMCH; &lt;100 m). Mesenteric venous thrombosis (MVT) comparisons were restricted to the overlapping period of 2020\u20132024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 186 patients in the high-altitude cohort and 549 in the low-altitude cohort, MVT was more frequent at high altitude (84.9% vs. 61.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). 158 high-altitude and 120 low-altitude patients with MVT were compared. Cirrhosis-related (29.1% vs. 11.7%) and erythrocytosis-related MVT (27.2% vs. 1.7%) were more common in the high-altitude cohort, whereas autoimmune disease-related MVT (0.6% vs. 11.7%) and thrombophilia (0 vs. 16.7%) were more frequent in the low-altitude cohort. High-altitude patients had higher hemoglobin\/hematocrit, bilirubin, and fibrinogen levels and a higher mean onset-to-admission time (95.4 vs. 30.2 days). They underwent surgery less frequently (29.7% vs. 80.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and had higher in-hospital mortality (26.6% vs. 11.7%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.004). Mortality was not significantly different among patients admitted within 2 days (31.6% vs. 8.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.111) but remained higher among those admitted after 2 days (25.9% vs. 12.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.012). Male sex, older age, alcohol consumption, smoking, and higher hematocrit, bilirubin, and fibrinogen were independently associated with the high-altitude MVT phenotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>AMI in the high-altitude population was characterized by a marked predominance of MVT, with distinct etiological and clinical profiles and poorer outcomes. These findings highlight the importance of early recognition, timely referral, and improved access to appropriate treatment for AMI in high-altitude settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15578682261497522","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:27:45Z","timestamp":1792056465000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Etiological and Clinical Patterns of Acute Mesenteric Ischemia at High Altitude: A Retrospective Comparative Study"],"prefix":"10.1177","author":[{"given":"Yonghao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."},{"name":"Department of Gastroenterology, People\u2019s Hospital of Xizang Autonomous Region, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, People\u2019s Hospital of Xizang Autonomous Region, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, People\u2019s Hospital of Xizang Autonomous Region, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."},{"name":"Department of Gastroenterology, People\u2019s Hospital of Xizang Autonomous Region, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.07.004"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-022-00443-x"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44551"},{"issue":"1","key":"e_1_3_5_5_1","first-page":"201","article-title":"Tibetan and Andean patterns of adaptation to high-altitude hypoxia","volume":"72","author":"Beall CM","year":"2000","unstructured":"Beall CM. 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