{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:38:03Z","timestamp":1780097883065,"version":"3.54.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>The aim of the study was to investigate the influence of therapeutic modalities and sexual hormone levels on changes in bone mineral density (BMD) in testicular cancer (TC) survivors. In a cross-sectional descriptive, long-term follow-up study, a total of 1,249 long-term TC survivors were evaluated according to treatment modality: orchiectomy (OE) only, OE + chemotherapy (CT), or OE + radiotherapy (RT). Luteinizing hormone (LH), total testosterone (TST), marker of bone resorption (\u03b2-carboxyl-terminal cross-linking telopeptide of type I collagen\u2014CTx), and BMD were evaluated. Standard statistical techniques were used to test the differences between groups of patients. TST decrease was observed in 46\/313 TC survivors after OE alone, in 103\/665 after OE + CT, and in 66\/271 after OE + RT. LH increase was observed in 23\/313 TC survivors after OE alone, in 154\/665 after OE + CT, and in 43\/271 after OE + RT. CTx increase was observed in 116\/313 TC survivors after OE alone, in 324\/665 after OE + CT, and in 82\/271 after OE + RT. Osteopenia\/osteoporosis occurred in 136\/313 TC survivors after OE alone, in 298\/665 after OE + CT, and in 139\/271 after OE + RT. TC survivors after RT have statistically significant decreased TST levels, increased LH and nonsignificant worse BMD (osteopenia\/osteoporosis) in comparison with TC survivors after OE alone or CT. TST decrease and LH increase were statistically significant, more frequently observed in patients with osteopenia\/osteoporosis. Examination of TST is an important part of follow-up in TC survivors with bilateral as well as unilateral disease. The important part of standard examination algorithm should be also the osteological examination of TC survivors mainly in patients with androgen deficiency.<\/jats:p>","DOI":"10.1177\/1557988316661986","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T20:28:29Z","timestamp":1470256109000},"page":"628-633","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Testosterone Deficiency and Bone Metabolism Damage in Testicular Cancer Survivors"],"prefix":"10.1177","volume":"12","author":[{"given":"Martina","family":"Ondrusova","sequence":"first","affiliation":[{"name":"St. Elisabeth University of Health and Social Science, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Spanikova","sequence":"additional","affiliation":[{"name":"St. Elisabeth Cancer Institute, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Sevcikova","sequence":"additional","affiliation":[{"name":"St. Elisabeth Cancer Institute, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalibor","family":"Ondrus","sequence":"additional","affiliation":[{"name":"St. Elisabeth Cancer Institute, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"bibr1-1557988316661986","unstructured":"Dohle G. R., Arver S., Bettocchi C., Jones T. H., Kliesch S., Punab M. (2015). Guidelines on male hypogonadism. 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