{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:01:23Z","timestamp":1779242483511,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["58210"],"award-info":[{"award-number":["58210"]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Klinefelter syndrome (KS) is a common sex chromosome-related abnormality seen among men. KS negatively affects spermatogenesis and testosterone production. It increases the risk of thrombosis but its molecular mechanism has not been well described yet. Elevated PAI-1 is a risk factor for thrombosis. The rs1799889 polymorphism located in the promoter region of the PAI-1 gene was detected in patients with deep venous thrombosis. In this study, the PAI-1 gene variant and its plasma levels in KS patients were examined. Forty-one KS patients (47, XXY) and 50 age-matched healthy controls participated. DNA was isolated from peripheral blood and a real-time PCR method was used to detect known SNPs in the PAI-1 gene. In addition, PAI-1 plasma levels were measured by using ELISA method. There was no significant difference between PAI-1 gene polymorphisms of KS patients and controls ( p &gt; .05). The significant difference was observed in PAI-1 plasma levels between two groups (high PAI-1 plasma level in KS patients compared to controls). The patients\u2019 group mean was 55.13 and control group mean in PAI-1 level was 29.89 ng\/ml ( p = .020). Clinical features related to thromboembolism especially varicose veins were detected in KS patients frequently ( p = .04). These results suggest that thromboembolism related to clinical features is seen more frequently in cases with KS, but it may not be dependent only on the PAI-1 gene polymorphism structure.<\/jats:p>","DOI":"10.1177\/1557988318801158","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T07:57:49Z","timestamp":1539849469000},"page":"2152-2156","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["The Effect of PAI-1 Gene Variants and PAI-1 Plasma Levels on Development of Thrombophilia in Patients With Klinefelter Syndrome"],"prefix":"10.1177","volume":"12","author":[{"given":"Burcin","family":"Erkal","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, \u0130stanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa School of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Kalayci Yigin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u0130stanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa School of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukru","family":"Palanduz","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Istanbul University, School of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Dasdemir","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u0130stanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa School of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-2039","authenticated-orcid":false,"given":"Mehmet","family":"Seven","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u0130stanbul University-Cerrahpa\u015fa, Cerrahpa\u015fa School of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"bibr1-1557988318801158","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.12.2511"},{"key":"bibr2-1557988318801158","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1981.tb00709.x"},{"key":"bibr3-1557988318801158","doi-asserted-by":"publisher","DOI":"10.1021\/bi00040a009"},{"issue":"11","key":"bibr4-1557988318801158","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.5858\/2002-126-1401-PAILAP","volume":"126","author":"Francis C. 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