{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:33:26Z","timestamp":1788449606115,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    One of the major causes of erectile dysfunction (ED) is an endothelial vascular disorder. This meta-analysis is performed to determine the efficacy of aspirin on erectile function in men with vasculogenic ED. For this purpose, CENTRAL, MEDLINE, and reference lists of articles up to November 2019 were searched. Randomized controlled trials (RCTs) were selected that compared aspirin with placebo in men of any ethnicity with vasculogenic ED. A total of 58 trials were retrieved. Finally, two trials of 214 men fulfilled our selection criteria. High selection and detection bias were identified for one trial. The participants showed a significant improvement in erectile function when they took aspirin (mean difference: 5.14, 95% CI [3.89, 6.40], and I\n                    <jats:sup>2<\/jats:sup>\n                    = 0%). Although the present meta-analysis suggested that aspirin has a significant effect on the improvement of erectile function, there were limited RCTs available on this topic and doses of aspirin varied. Additional studies are needed to support findings from this meta-analysis. Aspirin needs to be considered by practitioners when prescribing drugs for vasculogenic ED.\n                  <\/jats:p>","DOI":"10.1177\/1557988320969082","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T06:17:16Z","timestamp":1603865836000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of Aspirin for Vasculogenic Erectile Dysfunction in Men: A Meta-Analysis of Randomized Control Trials"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-2359","authenticated-orcid":false,"given":"Muhammad","family":"Irfan","sequence":"first","affiliation":[{"name":"Women\u2019s Health Development Unit, Universiti Sains Malaysia, Kelantan, Malaysia"},{"name":"Department of Zoology, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaiful Bahari","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhayati Mohd","family":"Noor","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9476-062X","authenticated-orcid":false,"given":"Nik Hazlina Nik","family":"Hussain","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Development Unit, Universiti Sains Malaysia, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"bibr1-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003402"},{"key":"bibr2-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-1786-0"},{"key":"bibr3-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400120048008"},{"key":"bibr4-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2005.08.007"},{"key":"bibr5-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0688-8"},{"key":"bibr6-1557988320969082","volume-title":"Organic impotence","author":"Ende J.","year":"1990","edition":"3"},{"key":"bibr7-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002907"},{"key":"bibr8-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901256"},{"key":"bibr9-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39490.551019.BE"},{"key":"bibr10-1557988320969082","first-page":"23","author":"Herschorn S.","year":"2003","journal-title":"The Canadian Journal of Urology, 10"},{"key":"bibr11-1557988320969082","volume-title":"Cochrane","author":"Higgins J. 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The Journal of Urology, 175(5), 1812\u20131816. doi: https:\/\/doi.org\/10.1016\/S0022-5347(05)01000-1.","DOI":"10.1016\/S0022-5347(05)01000-1"},{"key":"bibr24-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900846"},{"key":"bibr25-1557988320969082","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200017010-00006"},{"key":"bibr26-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.749135"},{"key":"bibr27-1557988320969082","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.3"}],"container-title":["American Journal of Men's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1557988320969082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1557988320969082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1557988320969082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:32:32Z","timestamp":1777505552000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1557988320969082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/1557988320969082"],"URL":"https:\/\/doi.org\/10.1177\/1557988320969082","relation":{},"ISSN":["1557-9883","1557-9891"],"issn-type":[{"value":"1557-9883","type":"print"},{"value":"1557-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"article-number":"1557988320969082"}}